White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status

IF 13 1区 医学 Q1 CLINICAL NEUROLOGY
Kyle C. Kern, Manu Vohra, Marissa L. Thirion, Danny J. J. Wang, Donna M. Wilcock, Jeffrey F. Thompson, Gary A. Rosenberg, Abhay Sagare, Abhay Moghekar, Hanzhang Lu, Tiffany Lee, Fanny M. Elahi, Claudia L. Satizabal, Russell Tracy, Sudha Seshadri, Kristin Schwab, Karl Helmer, Herpreet Singh, Pia Kivisäkk, Steven M. Greenberg, Keith Vossel, Joel H. Kramer, Pauline Maillard, Charles S. DeCarli, Jason D. Hinman
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引用次数: 0

Abstract

INTRODUCTION

Placental growth factor (PlGF) may regulate cerebrovascular permeability. We hypothesized that white matter interstitial fluid accumulation, estimated via magnetic resonance imaging (MRI) free water (FW), would explain the associations between elevated PlGF, white matter hyperintensities (WMH), and cognitive impairment.

METHODS

MarkVCID consortium participants ≥55 years old with plasma PlGF and brain MRI were included. We tested cross-sectionally whether FW mediated the associations between PlGF and WMH, or PlGF and cognition, measured using the Clinical Dementia Rating (CDR) scale and an executive function (EF) composite (Uniform Data Set version 3 [UDS3]-EF).

RESULTS

For 370 participants (mean age 72), a higher PlGF was associated with higher FW, higher WMH, and higher CDR, but not UDS3-EF. Higher FW was associated with higher WMH, higher CDR, and lower UDS3-EF. FW explained 26% of the association between PlGF and CDR and 73% of the association between PlGF and WMH.

DISCUSSION

Elevated PlGF may contribute to WMH and cognitive impairment through white matter FW accumulation.

CLINICAL TRIAL REGISTRATION

NCT06284213

Highlights

  • PlGF is a promising blood-based biomarker for vascular cognitive impairment.
  • In MarkVCID, higher PlGF was associated with accumulated white matter FW on MRI.
  • FW mediated the association between higher PlGF and MRI-visible white matter injury.
  • FW mediated the association between PlGF and worse CDR scale.
  • PlGF may contribute to cognitive dysfunction via accumulated interstitial fluid.

Abstract Image

白质游离水介导胎盘生长因子、白质高信号和认知状态之间的关联
胎盘生长因子(PlGF)可能调节脑血管通透性。我们假设,通过磁共振成像(MRI)游离水(FW)估计的白质间质积液可以解释PlGF升高、白质高信号(WMH)和认知障碍之间的关联。
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来源期刊
Alzheimer's & Dementia
Alzheimer's & Dementia 医学-临床神经学
CiteScore
14.50
自引率
5.00%
发文量
299
审稿时长
3 months
期刊介绍: Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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