Bicontinuous Nanoparticles from Spontaneous Self-Assembly of Block Copolymer Prodrug in Aqueous Medium for Potential Cancer Therapy

IF 5.1 Q1 POLYMER SCIENCE

ACS Macro Letters Pub Date : 2024-12-18 DOI:10.1021/acsmacrolett.4c00590

Juthi Pal, Pousali Samanta, Afruja Khan, Rishabh Maity, Amirul Islam Mallick, Dibakar Dhara

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Abstract

Despite having several advantages, bicontinuously structured polymeric nanoparticles (BSPNPs) are far less explored in the field of controlled drug delivery owing to the requirement of complex precursor copolymers and the associated multistep synthetic procedures. In this work, we report the synthesis of a redox-sensitive diblock copolymer (P1), which was subsequently utilized to prepare doxorubicin (DOX) containing a pH-labile prodrug (P2). P1 and P2 spontaneously self-assembled in aqueous media above their critical aggregation concentration, forming micellar nanoparticles with rare bicontinuous morphology that promotes loading of both hydrophobic and hydrophilic cargoes in different compartments. To the best of our knowledge, the formation of BSPNPs through direct self-assembly in aqueous media has not yet been reported. In vitro cellular studies asserted the higher safety profile of the nanoparticles against noncancerous cells (HEK293T) than free DOX, whereas they displayed higher drug-induced cytotoxicity against cancer cells (MCF-7) in comparison to free DOX, establishing them as promising cancer drug delivery systems.

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嵌段共聚物前体药物在水介质中自发自组装的双连续纳米颗粒用于潜在的癌症治疗

尽管双连续结构聚合物纳米颗粒（BSPNPs）具有许多优点，但由于需要复杂的前体共聚物和相关的多步骤合成程序，其在受控药物递送领域的研究还远远不够。在这项工作中，我们报道了一种氧化还原敏感的二嵌段共聚物（P1）的合成，随后用于制备含有ph不稳定前药（P2）的阿霉素（DOX）。P1和P2在超过临界聚集浓度的水介质中自发自组装，形成具有罕见双连续形态的胶束纳米颗粒，促进在不同隔间中装载疏水和亲水货物。据我们所知，在水介质中通过直接自组装形成BSPNPs尚未有报道。体外细胞研究表明，纳米颗粒对非癌细胞（HEK293T）的安全性高于游离DOX，而它们对癌细胞（MCF-7）的药物诱导毒性高于游离DOX，这使它们成为有前景的癌症药物输送系统。

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来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.