Trichuriasis in Human Patients from Côte d’Ivoire Caused by Novel Species Trichuris incognita with Low Sensitivity to Albendazole/Ivermectin Combination Treatment

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2024-12-18 DOI:10.3201/eid3101.240995

Abhinaya Venkatesan, Rebecca Chen, Max Bär, Pierre H.H. Schneeberger, Brenna Reimer, Eveline Hürlimann, Jean T. Coulibaly, Said M. Ali, Somphou Sayasone, John Soghigian, Jennifer Keiser, John Stuart Gilleard

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Abstract

Albendazole/ivermectin combination therapy is a promising alternative to benzimidazole monotherapy alone for Trichuris trichiura control. We used fecal DNA metabarcoding to genetically characterize Trichuris spp. populations in patient samples from Côte d’Ivoire showing lower (egg reduction rate <70%) albendazole/ivermectin sensitivity than those from Laos and Tanzania (egg reduction rates >98%). Internal transcribed spacer (ITS) 1 and ITS2 metabarcoding revealed the entire detected Côte d'Ivoire Trichuris population was phylogenetically distinct from T. trichiura found in Laos and Tanzania and was more closely related to T. suis. Mitochondrial genome sequencing of 8 adult Trichuris worms from Côte d’Ivoire confirmed their species-level differentiation. Sequences from human patients in Cameroon and Uganda and 3 captive nonhuman primates suggest this novel species, T. incognita, is distributed beyond Côte d'Ivoire and has zoonotic potential. Continued surveillance by using fecal DNA metabarcoding will be needed to determine Trichuris spp. geographic distribution and control strategies.

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在控制毛滴虫方面，阿苯达唑/伊维菌素联合疗法是苯并咪唑单药疗法的一种很有前途的替代疗法。我们利用粪便 DNA 代谢编码技术对科特迪瓦患者样本中的毛滴虫种群进行了基因鉴定，结果表明其对阿苯达唑/伊维菌素的敏感性（虫卵减少率<70%）低于老挝和坦桑尼亚（虫卵减少率>98%）。内部转录间隔（ITS）1和ITS2元编码显示，整个检测到的科特迪瓦毛滴虫种群在系统发育上与老挝和坦桑尼亚的毛滴虫不同，与T. suis的亲缘关系更近。对科特迪瓦的 8 个毛滴虫成虫进行的线粒体基因组测序证实了它们的物种分化。来自喀麦隆和乌干达的人类患者以及 3 只人工饲养的非人灵长类动物的序列表明，这种新物种 T. incognita 分布在科特迪瓦以外的地区，具有人畜共患病的可能性。为了确定毛滴虫属的地理分布和控制策略，需要继续使用粪便 DNA 代谢编码进行监测。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.