Quantification of Epigenetic Aging in Public Health.

IF 21.4 1区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annual Review of Public Health Pub Date : 2024-12-16 DOI:10.1146/annurev-publhealth-060222-015657

Cynthia D J Kusters, Steve Horvath

引用次数: 0

Abstract

Estimators of biological age hold promise for use in preventive medicine, for early detection of chronic conditions, and for monitoring the effectiveness of interventions aimed at improving population health. Among the promising biomarkers in this field are DNA methylation-based biomarkers, commonly referred to as epigenetic clocks. This review provides a survey of these clocks, with an emphasis on second-generation clocks that predict human morbidity and mortality. It explores the validity of epigenetic clocks when considering factors such as race, sex differences, lifestyle, and environmental influences. Furthermore, the review addresses the current challenges and limitations in this research area.

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生物年龄的估算有望用于预防医学、慢性病的早期检测以及监测旨在改善人口健康的干预措施的有效性。在这一领域，基于 DNA 甲基化的生物标记物（通常称为表观遗传时钟）是最有前途的生物标记物之一。本综述对这些时钟进行了调查，重点是预测人类发病率和死亡率的第二代时钟。它探讨了在考虑种族、性别差异、生活方式和环境影响等因素时，表观遗传时钟的有效性。此外，该综述还探讨了这一研究领域目前面临的挑战和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

26.60

自引率

1.40%

发文量

审稿时长

>12 weeks

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