A new aglycone derivative from the saprophytic fungus Tubeufia rubra.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-17 DOI:10.1080/14786419.2024.2424391

Xin Li, Wen Zheng, Long Han, Zhang-Jiang He, Ji-Chuan Kang

引用次数: 0

Abstract

A new aglycone derivative (1) and five known compounds (2-6) have been isolated from a saprophytic fungus Tubeufia rubra for the first time. Their structures and absolute configurations were determined by nuclear magnetic resonance, high resolution mass spectrometry data and electronic circular dichroism. The bioactivities of all compounds were evaluated by cell analysis. Compound 5 showed significant toxicity to human cancer A549 cells, and the IC₅₀ value was 32. 89 μg/mL. Compound 6 could reverse the multidrug resistance of A549/DDP cells, and the reversal value was 2.92. With the extension of the action time, the IC50 value of compound 6 decreased from 424.72 μg/mL at 24 h to 9.45 μg/mL at 72 h.

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首次从红管真菌（Tubeufia rubra）中分离出了一种新的琼脂酮衍生物（1）和五种已知化合物（2-6）。通过核磁共振、高分辨率质谱数据和电子圆二色性测定了它们的结构和绝对构型。通过细胞分析评估了所有化合物的生物活性。化合物 5 对人类癌症 A549 细胞有明显毒性，其 IC50 值为 32.89 μg/mL。化合物 6 能逆转 A549/DDP 细胞的多药耐药性，逆转值为 2.92。随着作用时间的延长，化合物 6 的 IC50 值从 24 h 时的 424.72 μg/mL 降至 72 h 时的 9.45 μg/mL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.