Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical Devices.

IF 4.4 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Nanomaterials Pub Date : 2024-11-26 DOI:10.3390/nano14231899

James Hall, Subbareddy Mekapothula, Rebecca Coxhill, Dominic Craske, Adam M Varney, Gareth W V Cave, Samantha McLean

引用次数: 0

Abstract

Copper oxide nanoparticles (CuONPs) offer promising antimicrobial properties against a range of pathogens, addressing the urgent issue of antibiotic resistance. This study details the synthesis of glutamic acid-coated CuONPs (GA-CuONPs) and their functionalisation on medical-grade silicone tubing, using an oxysilane bonding agent. The resulting coating shows significant antimicrobial activity against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains, while remaining non-toxic to human cells and exhibiting stable adherence, without leaching. This versatile coating method can be applied during manufacturing, or for ad hoc modifications, enhancing the antimicrobial properties of medical devices.

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氧化铜纳米粒子（CuONPs）对一系列病原体具有良好的抗菌性能，可解决抗生素耐药性这一紧迫问题。本研究详细介绍了谷氨酸涂层 CuONPs（GA-CuONPs）的合成及其在医用级硅胶管上的功能化，使用的是一种草酰硅烷粘接剂。由此产生的涂层对革兰氏阳性和革兰氏阴性细菌（包括耐多药菌株）都有明显的抗菌活性，同时对人体细胞无毒，并表现出稳定的附着性，不会发生浸出。这种多功能涂层方法可在生产过程中使用，也可用于临时改装，从而增强医疗器械的抗菌性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanomaterials NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

8.50

自引率

9.40%

发文量

3841

审稿时长

14.22 days

期刊介绍： Nanomaterials (ISSN 2076-4991) is an international and interdisciplinary scholarly open access journal. It publishes reviews, regular research papers, communications, and short notes that are relevant to any field of study that involves nanomaterials, with respect to their science and application. Thus, theoretical and experimental articles will be accepted, along with articles that deal with the synthesis and use of nanomaterials. Articles that synthesize information from multiple fields, and which place discoveries within a broader context, will be preferred. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental or methodical details, or both, must be provided for research articles. Computed data or files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Nanomaterials is dedicated to a high scientific standard. All manuscripts undergo a rigorous reviewing process and decisions are based on the recommendations of independent reviewers.