Engineering Zn/Fe Mixed Metal Oxides with Tunable Structural and Magnetic Properties for Magnetic Particle Imaging.

IF 4.4 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Nanomaterials Pub Date : 2024-12-07 DOI:10.3390/nano14231964

Qianyi Zhang, Bing Sun, Saeed Shanehsazzadeh, Andre Bongers, Zi Gu

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引用次数: 0

Abstract

Engineering magnetic nanoparticles with tunable structural properties and magnetism is critical to develop desirable magnetic particle imaging (MPI) tracers for biomedical applications. Here we present a new superparamagnetic metal oxide nanoparticle with a controllable chemical composition and magnetism for imaging tumor xenografts in living mice. Superparamagnetic Zn/Fe mixed metal oxide (ZnFe-MMO) nanoparticles are fabricated via a facile one-pot co-precipitation method in water followed by thermal decomposition with tunable Zn/Fe ratios and at various calcination temperatures. This work, for the first time, presented LDH-derived metal oxides for an MPI application. The metal composition is tunable to present an optimized MPI performance. The analytical results demonstrate that ZnFe-MMO nanoparticles at the designed molar ratio of Zn/Fe = 2:1 after 650 °C calcination demonstrate a higher saturation magnetization (M_S) value and optimal MPI signal than the samples presented with other conditions. The excellent biocompatibility of ZnFe-MMO is demonstrated in both breast cancer cells and fibroblast cell cultures. In vivo imaging of 4T1 tumor xenografts in mice using ZnFe-MMO as a tracer showed that the mean signal intensity is 1.27-fold higher than the commercial tracer VivoTrax at 72 h post-injection, indicating ZnFe-MMO's promise for prolonged MPI imaging applications.

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要为生物医学应用开发出理想的磁粉成像（MPI）示踪剂，就必须设计出具有可调结构特性和磁性的磁性纳米粒子。在此，我们介绍了一种新型超顺磁性金属氧化物纳米粒子，其化学成分和磁性可控，可用于对活体小鼠体内的肿瘤异种移植物进行成像。超顺磁性 Zn/Fe 混合金属氧化物（ZnFe-MMO）纳米粒子是在水中通过简单的一锅共沉淀法制成的，然后在不同的煅烧温度下以可调的 Zn/Fe 比例进行热分解。这项工作首次提出了用于 MPI 应用的 LDH 衍生金属氧化物。金属成分可调，以实现最佳的 MPI 性能。分析结果表明，在 650 °C 煅烧后，ZnFe-MMO 纳米粒子的设计摩尔比为 Zn/Fe = 2:1，与其他条件下的样品相比，具有更高的饱和磁化（MS）值和最佳 MPI 信号。ZnFe-MMO 在乳腺癌细胞和成纤维细胞培养中都表现出了良好的生物相容性。使用 ZnFe-MMO 作为示踪剂对小鼠体内的 4T1 肿瘤异种移植进行的体内成像显示，在注射后 72 小时内，平均信号强度是商用示踪剂 VivoTrax 的 1.27 倍，这表明 ZnFe-MMO 有希望用于长时间 MPI 成像应用。

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来源期刊

Nanomaterials NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

8.50

自引率

9.40%

发文量

3841

审稿时长

14.22 days

期刊介绍： Nanomaterials (ISSN 2076-4991) is an international and interdisciplinary scholarly open access journal. It publishes reviews, regular research papers, communications, and short notes that are relevant to any field of study that involves nanomaterials, with respect to their science and application. Thus, theoretical and experimental articles will be accepted, along with articles that deal with the synthesis and use of nanomaterials. Articles that synthesize information from multiple fields, and which place discoveries within a broader context, will be preferred. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental or methodical details, or both, must be provided for research articles. Computed data or files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Nanomaterials is dedicated to a high scientific standard. All manuscripts undergo a rigorous reviewing process and decisions are based on the recommendations of independent reviewers.