Prognostic Factors in Head and Neck Cancer: A Retrospective Cohort Study of 3052 Patients in Brazil.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-12-17 DOI:10.1111/odi.15196

Ana Letícia Mores, Carolina Guimarães Bonfim-Alves, Rossana Verónica Mendoza López, Leticia Rodrigues-Oliveira, Natália Rangel Palmier, Bruno Augusto Linhares Almeida Mariz, Cesar Augusto Migliorati, Luiz Paulo Kowalski, Alan Roger Santos-Silva, Thaís Bianca Brandão, Ana Carolina Prado-Ribeiro

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引用次数: 0

Abstract

Objective: Evaluate the sociodemographic, clinical, and lifestyle characteristics at head and neck squamous cell carcinoma (HNSCC) diagnosis and their impact on overall survival (OS) across different anatomical sites.

Materials and methods: A retrospective cohort study (2011-2021) at Instituto do Câncer do Estado de São Paulo, involving 3052 HNSCC patients. Survival analyses utilized the Kaplan-Meier method and Cox proportional hazard ratios with 95% confidence intervals, incorporating significant variables from univariate analysis.

Results: The five-year OS for all HNSCC sites (n = 3052) was 31.4%, with specific rates of 37.0% for laryngeal cancer (n = 935), 35.8% for oral cancer (n = 762), 26.6% for oropharyngeal cancer (OPC) (n = 1189), and 14.8% for hypopharyngeal cancer (n = 166). HPV-positive OPC had a higher five-year OS (59.3%; n = 127) compared to HPV-negative (35.4%; n = 226). Multivariable analysis identified older age (≥ 70 years) and advanced TNM stage (IV) as adverse prognostic factors for oral cavity, oropharynx, and larynx sites. Male gender was associated with poorer prognosis in the oral cavity, while alcohol consumption was linked to worse outcomes in oropharynx and larynx sites.

Conclusion: HNSCC OS remains low at a public cancer center in São Paulo. Older age, advanced tumor stage, and alcohol consumption are independent adverse prognostic factors, particularly in oropharynx and larynx sites.

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头颈癌的预后因素：巴西3052例患者的回顾性队列研究

摘要评估头颈部鳞状细胞癌（HNSCC）确诊时的社会人口学、临床和生活方式特征及其对不同解剖部位总生存率（OS）的影响：圣保罗州癌症研究所的一项回顾性队列研究（2011-2021年），涉及3052名HNSCC患者。生存期分析采用卡普兰-梅耶法和带有95%置信区间的Cox比例危险比，并纳入了单变量分析中的重要变量：所有HNSCC部位（n = 3052）的五年OS率为31.4%，其中喉癌（n = 935）、口腔癌（n = 762）、口咽癌（OPC）（n = 1189）和下咽癌（n = 166）的具体比率分别为37.0%、35.8%、26.6%和14.8%。与HPV阴性（35.4%；n = 226）相比，HPV阳性OPC的五年OS更高（59.3%；n = 127）。多变量分析发现，年龄较大（≥ 70 岁）和 TNM 分期较晚（IV 期）是口腔、口咽和喉部位的不良预后因素。男性与口腔预后较差有关，而饮酒与口咽和喉部预后较差有关：结论：在圣保罗的一家公立癌症中心，HNSCC的OS仍然很低。高龄、肿瘤晚期和饮酒是独立的不良预后因素，尤其是在口咽和喉部。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.