[Serum and mandible alterations of antibiotics levels under increased serum FFA].

Abstract

The levels of three antibiotics (Cefapirin, Doxycycline, Gentamicin) were studied in an experimental model (swimming stress) with elevated serum FFA. Sixty Wistar rats were in three groups used divided. Each group consisted of 3 subgroups. The subgroups A and B were submitted in swimming stress procedure for 10 and 20 days. The subgroup C was the control group. Since stress increases the FFA the concentration of antibiotics in blood and bone are influenced. According to the estimation of the result the following were observed: 1) Increase of FFA in stress groups 2) Weight increase of adrenals in stress groups which means that the stress procedure was effective 3) Increase of cefapirin level 4) Increase of doxycyclin 5) Increase of gentamicin 6) Increase of haematocrite.