Respiratory syncytial virus infection in patients with haematological diseases: a retrospective multicentre study.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2024-12-17 DOI:10.1007/s15010-024-02449-w

Sebastian Herrmann, Stephanie Graefe, Maximilian Christopeit, Piet Sonnemann, Tessa Hattenhauer, Rebekka Mispelbaum, Malte B Monin, Hans Martin Orth, Charlotte Flasshove, Henning Gruell, Florian Klein, Uwe Klein, Clara Lehmann, Jan-Hendrik Naendrup, Jannik Stemler, Jon Salmanton-Garcia, Theresa Markus, Oliver A Cornely, Sibylle C Mellinghoff

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引用次数: 0

Abstract

Purpose: This study aims to evaluate the burden of respiratory syncytial virus (RSV) infections in patients with haematological diseases. It seeks to analyse the relevance of prevention, diagnosis and treatment of RSV infections.

Methods: A multi-centre, retrospective study was conducted across University Hospitals in Cologne, Düsseldorf, Bonn, and the University Medical Centre Hamburg-Eppendorf between Jan 2016 and Aug 2023. All haematological patients with diagnosed RSV infection were included. The study focused on the incidence of RSV, underlying conditions, comorbidities, coinfections and clinical outcomes such as hospitalization, intensive care unit (ICU) admission and mortality.

Results: Of 166 patients, 89 (53.6%) had signs of pneumonia and 37 (22.3%) were admitted to ICU due to RSV infection, while 20 (54%) of those were mechanically ventilated with median duration of 11 days (1,33; IQR:18). Mean age was 60 years (range 14-88). Sixteen patients (9.6%) were treated as outpatients, while 52 (31.3%) were hospitalized due to RSV infection; the median hospital stay was 16 days (IQR 25.25, range 0-97). 79 (47.6%) of patients presented with leukopenia and 57 (34.3%) with neutropenia. In total, 22 patients (13.3%) died within 30 days and 29 (17.5%) died within 90 days. Highest mortality rates were seen in patients with aggressive lymphoma (23.5%) and acute leukaemia (18%).

Conclusion: RSV significantly impacts patients with haematological diseases, leading to high rates of hospitalization, ICU admission, and mortality. Preventive measures, such as vaccination, alongside early diagnosis and individualized management, are essential to reduce RSV-associated morbidity and mortality in this high-risk population.

查看原文本刊更多论文

血液病患者的呼吸道合胞病毒感染：一项回顾性多中心研究。

目的：本研究旨在评估血液病患者的呼吸道合胞病毒（RSV）感染负担。方法：在德累斯顿大学医院进行了一项多中心回顾性研究：方法：2016 年 1 月至 2023 年 8 月期间，在科隆、杜塞尔多夫、波恩的大学医院和汉堡大学医疗中心（University Medical Centre Hamburg-Eppendorf）开展了一项多中心回顾性研究。所有确诊感染 RSV 的血液病患者均被纳入研究范围。研究重点是RSV的发病率、基础疾病、并发症、合并感染以及住院、入住重症监护室（ICU）和死亡率等临床结果：在166名患者中，89人（53.6%）有肺炎症状，37人（22.3%）因RSV感染入住重症监护室，其中20人（54%）接受了机械通气，中位持续时间为11天（1,33；IQR：18）。平均年龄为 60 岁（14-88 岁不等）。16名患者（9.6%）在门诊接受治疗，52名患者（31.3%）因感染 RSV 而住院；住院时间中位数为 16 天（IQR 25.25，范围 0-97）。79名患者（47.6%）出现白细胞减少症，57名患者（34.3%）出现中性粒细胞减少症。共有 22 名患者（13.3%）在 30 天内死亡，29 名患者（17.5%）在 90 天内死亡。死亡率最高的是侵袭性淋巴瘤患者（23.5%）和急性白血病患者（18%）：结论：RSV 对血液病患者的影响很大，导致住院率、重症监护室入院率和死亡率居高不下。疫苗接种等预防措施以及早期诊断和个体化管理对于降低 RSV 相关高危人群的发病率和死亡率至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.