Interplay between lncRNAs and microrNAs in hypertension.

IF 4.3 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Hypertension Research Pub Date : 2024-12-17 DOI:10.1038/s41440-024-01888-0

Gokul Sudhakaran

引用次数: 0

Abstract

The interplay between long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in regulating hypertension modulate gene expression through different mechanisms, influencing key physiological and pathological processes. Specifically, interactions between lncRNAs and miRNAs affect various molecular pathways, including the renin-angiotensin-aldosterone system, which plays a critical role in blood pressure regulation. The lncRNA MALAT1 is particularly noted for its role in inflammation and oxidative stress regulation, suggesting potential targets for hypertension treatment and diagnostics. Interplay between lncRNAs and MicroRNAs in Hypertension.

查看原文本刊更多论文

lncrna和microrna在高血压中的相互作用。

长非编码 RNA（lncRNA）和 microRNA（miRNA）在调控高血压方面的相互作用通过不同的机制调节基因表达，影响关键的生理和病理过程。具体来说，lncRNA 和 miRNA 之间的相互作用会影响各种分子通路，包括在血压调节中发挥关键作用的肾素-血管紧张素-醛固酮系统。lncRNA MALAT1 在炎症和氧化应激调节中的作用尤其引人注意，为高血压治疗和诊断提供了潜在靶点。高血压中 lncRNA 与 MicroRNA 之间的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Hypertension Research 医学-外周血管病

CiteScore

7.40

自引率

16.70%

发文量

249

审稿时长

3-8 weeks

期刊介绍： Hypertension Research is the official publication of the Japanese Society of Hypertension. The journal publishes papers reporting original clinical and experimental research that contribute to the advancement of knowledge in the field of hypertension and related cardiovascular diseases. The journal publishes Review Articles, Articles, Correspondence and Comments.