Digital Rehabilitation Program for Breast Cancer Survivors on Adjuvant Hormonal Therapy: A Feasibility Study.

IF 4.5 2区 医学 Q1 ONCOLOGY
Cancers Pub Date : 2024-12-05 DOI:10.3390/cancers16234084
Wing-Lok Chan, Yat-Lam Wong, Yin-Ling Tai, Michelle Liu, Bryan Yun, Yuning Zhang, Holly Li-Yu Hou, Dora Kwong, Victor Ho-Fun Lee, Wendy Wing-Tak Lam
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引用次数: 0

Abstract

Background: Breast cancer survivors often face physical and psychological challenges, including weight gain, metabolic syndrome, and reduced quality of life. To address these concerns, a mobile app-based rehabilitation program called "THRIVE" was developed to improve physical activity, medication adherence, and health-related quality of life (HRQoL) in this population. Methods: This prospective, single-arm study assessed the feasibility and effectiveness of the "THRIVE" app among breast cancer survivors undergoing hormonal therapy. Participants were recruited from Queen Mary Hospital in Hong Kong between December 2022 and June 2023. Eligible survivors had completed treatment within the last five years or had stable advanced disease on hormonal therapy. Participants monitored their exercise, medication adherence, and self-care via the app and a Fitbit activity tracker for 16 weeks. Primary outcomes included recruitment, dropout, adherence rates, and safety. Secondary outcomes, measured at baseline and week 16, included physical activity intensity, HRQoL, psychological stress, body composition, and app satisfaction. Results: A total of 50 participants, with a median age of 53 years, completed the study. The recruitment rate was 70.4% with no dropouts. The adherence rate, measured by completing exercises recommended in the mobile app at least three times per week, was 74%. No severe adverse events were reported. While physical activity intensity showed no significant changes from baseline to week 16 (p = 0.24), cognitive function (p = 0.021), future perspective (p = 0.044), arm symptoms (p = 0.042), depression (p = 0.01), and anxiety (p = 0.004) improved. All participants reported perfect medication compliance (100%). Satisfaction with the app was high. Conclusions: This mobile app-based rehabilitation program demonstrated good feasibility, with satisfactory recruitment, adherence, and safety, providing valuable insights into future definitive studies.

乳腺癌幸存者辅助激素治疗的数字康复计划:可行性研究。
背景:乳腺癌幸存者经常面临身体和心理上的挑战,包括体重增加、代谢综合征和生活质量下降。为了解决这些问题,一个名为“THRIVE”的基于移动应用程序的康复项目被开发出来,以改善这一人群的身体活动、药物依从性和与健康相关的生活质量(HRQoL)。方法:这项前瞻性单臂研究评估了“THRIVE”应用程序在接受激素治疗的乳腺癌幸存者中的可行性和有效性。参与者是在2022年12月至2023年6月期间从香港玛丽医院招募的。符合条件的幸存者在过去五年内完成治疗或在激素治疗中病情稳定。参与者通过应用程序和Fitbit活动追踪器监测他们的锻炼、药物依从性和自我保健,持续16周。主要结局包括招募、退出、依从率和安全性。在基线和第16周测量的次要结果包括身体活动强度、HRQoL、心理压力、身体成分和应用程序满意度。结果:共有50名参与者完成了研究,中位年龄为53岁。录取率为70.4%,无辍学率。通过每周至少完成三次移动应用程序推荐的锻炼来衡量,坚持率为74%。无严重不良事件报告。虽然从基线到第16周体力活动强度没有显著变化(p = 0.24),但认知功能(p = 0.021)、对未来的看法(p = 0.044)、手臂症状(p = 0.042)、抑郁(p = 0.01)和焦虑(p = 0.004)得到改善。所有参与者报告完全的药物依从性(100%)。用户对这款应用的满意度很高。结论:该基于移动应用程序的康复方案具有良好的可行性,具有令人满意的招募,依从性和安全性,为未来的明确研究提供了有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancers
Cancers Medicine-Oncology
CiteScore
8.00
自引率
9.60%
发文量
5371
审稿时长
18.07 days
期刊介绍: Cancers (ISSN 2072-6694) is an international, peer-reviewed open access journal on oncology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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