Fractionating impulsivity and reward-related phenotypes in adolescent mice.

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES
Ruth Albert-Lyons, Stephanie S Desrochers, Catherine Fengler, Katherine M Nautiyal
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引用次数: 0

Abstract

Adolescence is a developmental period characterized by changes in the brain and behavior, including heightened reward seeking, increased impulsivity, and elevated risk-taking behavior. It is also a sensitive period for the development of a number of behavioral and psychiatric disorders associated with pathological phenotypes of reward processing and impulsivity. Landmark human studies are charting the development of impulsivity and other reward-related phenotypes to identify the facets and timecourse of the adolescent phenotype. Collecting similar data from mice is important to enable molecular, cellular, and circuit-level interrogation of adolescent maturation of reward, motivation, and impulsive behavior. These complex phenotypes have traditionally been difficult to assay in adolescent mice. Here, using a combination of approaches including homecage testing, we tested a number of facets of reward seeking, impulsivity, motivation, and incentive salience attribution during adolescent development. We found that adolescent mice show increased reward seeking, impulsive action, and motivation. Interestingly, we found no effect of adolescence on impulsive choice, sign-tracking, reward-learning, or conditioned reinforcement. Overall, our studies set the stage for approaches to study multi-faceted phenotypes related to impulsivity and other reward-related behaviors in adolescent mice to examine the developmental trajectories of brain and behavior.

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来源期刊
Behavioural Brain Research
Behavioural Brain Research 医学-行为科学
CiteScore
5.60
自引率
0.00%
发文量
383
审稿时长
61 days
期刊介绍: Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
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