The Efficacy and Safety of Botulinum Toxin Type A in Prevention of Hypertrophic Scars After Epicanthoplasty: A Split-Face Double-Blinded Randomized Controlled Trial.
Dandan Liu, Yanting Ou, Lin Luo, Mengfan Wu, Yihan Zhang, Luotai Chen, Zhuolin Liu, Tingyin Lin, Xiangwen Xu, Yongyan Cui
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引用次数: 0
Abstract
Background: Timely intervention can improve the aesthetic outcome of surgical scars, and botulinum toxin type A (BTXA) has demonstrated its potential as an effective treatment. However, conclusive scientific evidence is needed to definitively confirm the specific efficacy of BTXA following epicanthoplasty.
Methods: A total of 21 patients who underwent epicanthoplasty were enrolled. Either BTXA or normal saline was randomly injected into the left or right epicanthus immediately after epicanthoplasty. The efficacy of scar prevention was assessed at a 1-month and 6-month follow-up visit using various assessment scales, and scar widths were also measured. The safety assessment included evaluating the complications and adverse effects after injections.
Results: Totally, 20 patients completed the entire follow-up period. At 6-month follow-up, significant improvements were noted (P<0.05) in the treatment group compared to the control group across all evaluated metrics: the Modified Stony Brook Scar Evaluation Scale (total scores: 6.73±1.26 vs 5.75±1.60), Observer Scar Assessment Scale (total scores: 6.35±5.93 vs 8.55±5.65), Patient Scar Assessment Scale (color scores: 1.10±1.17 vs 1.85±1.69), Visual Analog Scale (total scores: 8.48±1.24 vs 7.94±1.37), and the average scar widths (0.37±0.18mm vs 0.68±0.42mm). No adverse effects were observed.
Conclusions: BTXA can effectively prevent scar hyperplasia after epicanthoplasty, especially in improving scar pigmentation, width, and softness.
Level of evidence ii: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
期刊介绍：
Aesthetic Plastic Surgery is a publication of the International Society of Aesthetic Plastic Surgery and the official journal of the European Association of Societies of Aesthetic Plastic Surgery (EASAPS), Società Italiana di Chirurgia Plastica Ricostruttiva ed Estetica (SICPRE), Vereinigung der Deutschen Aesthetisch Plastischen Chirurgen (VDAPC), the Romanian Aesthetic Surgery Society (RASS), Asociación Española de Cirugía Estética Plástica (AECEP), La Sociedad Argentina de Cirugía Plástica, Estética y Reparadora (SACPER), the Rhinoplasty Society of Europe (RSE), the Iranian Society of Plastic and Aesthetic Surgeons (ISPAS), the Singapore Association of Plastic Surgeons (SAPS), the Australasian Society of Aesthetic Plastic Surgeons (ASAPS), the Egyptian Society of Plastic and Reconstructive Surgeons (ESPRS), and the Sociedad Chilena de Cirugía Plástica, Reconstructiva y Estética (SCCP).
Aesthetic Plastic Surgery provides a forum for original articles advancing the art of aesthetic plastic surgery. Many describe surgical craftsmanship; others deal with complications in surgical procedures and methods by which to treat or avoid them. Coverage includes "second thoughts" on established techniques, which might be abandoned, modified, or improved. Also included are case histories; improvements in surgical instruments, pharmaceuticals, and operating room equipment; and discussions of problems such as the role of psychosocial factors in the doctor-patient and the patient-public interrelationships.
Aesthetic Plastic Surgery is covered in Current Contents/Clinical Medicine, SciSearch, Research Alert, Index Medicus-Medline, and Excerpta Medica/Embase.
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