Maternal concentrations of perfluoroalkyl sulfonates and alterations in white matter microstructure in the developing brains of young children.

Abstract

Background: Maternal exposure to per- and polyfluoroalkyl substances (PFAS) has been linked to child neurodevelopmental difficulties. Neuroimaging research has linked these neurodevelopmental difficulties to white matter microstructure alterations, but the effects of PFAS on children's white matter microstructure remains unclear. We investigated associations between maternal blood concentrations of six common perfluoroalkyl sulfonates and white matter alterations in young children using longitudinal neuroimaging data.

Methods: This study included 84 maternal-child pairs from a Canadian pregnancy cohort. Maternal second trimester blood concentrations of perfluorohexanesulfonate (PFHxS) and five perfluorooctane sulfonate (PFOS) isomers were quantified. Children underwent magnetic resonance imaging scans between ages two and six (279 scans total). Adjusted linear mixed models investigated associations between each exposure and white matter fractional anisotropy (FA) and mean diffusivity (MD).

Results: Higher maternal concentrations of perfluoroalkyl sulfonates were associated with higher MD and lower FA in the body and splenium of the corpus callosum of young children. Multiple sex-specific associations were found. In males, PFHxS was negatively associated with FA in the superior longitudinal fasciculus, while PFOS isomers were positively associated with MD in the inferior longitudinal fasciculus (ILF). In females, PFOS isomers were positively associated with FA in the pyramidal fibers and MD in the fornix, but negatively associated with MD in the ILF.

Conclusion: Maternal exposure to perfluoroalkyl sulfonates may alter sex-specific white matter development in young children, potentially contributing to neurodevelopmental difficulties. Larger studies are needed to replicate these findings and examine the neurotoxicity of these chemicals.