{"title":"Vanadium Complexes for Mitochondria-Targeted Photodynamic Therapy.","authors":"Md Kausar Raza, Arun Kumar","doi":"10.1002/cbic.202400901","DOIUrl":null,"url":null,"abstract":"<p><p>This minireview focuses on vanadium complexes in photodynamic therapy (PDT), particularly for their potential as mitochondria-targeted anticancer agents. Vanadium's coordination versatility supports its bioactivity, showing promise in insulin-mimetic, lipid-lowering, and antitumor effects. PDT leverages these complexes' redox properties, producing reactive oxygen species (ROS) within mitochondria to induce cancer cell apoptosis with minimal impact on healthy cells. The review covers design strategies to improve mitochondrial localization, photodynamic efficiency, and selective cytotoxicity while addressing challenges like photostability and targeting for next-gen PDT applications.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202400901"},"PeriodicalIF":2.6000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/cbic.202400901","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This minireview focuses on vanadium complexes in photodynamic therapy (PDT), particularly for their potential as mitochondria-targeted anticancer agents. Vanadium's coordination versatility supports its bioactivity, showing promise in insulin-mimetic, lipid-lowering, and antitumor effects. PDT leverages these complexes' redox properties, producing reactive oxygen species (ROS) within mitochondria to induce cancer cell apoptosis with minimal impact on healthy cells. The review covers design strategies to improve mitochondrial localization, photodynamic efficiency, and selective cytotoxicity while addressing challenges like photostability and targeting for next-gen PDT applications.
期刊介绍:
ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).