Effect of Gonadotropin-Releasing Hormone Agonist Pre-Treatment on Outcomes of Fresh and Frozen Embryo Transfers in Women With Adenomyosis: A Retrospective Cohort Study With Literature Review

IF 4.7 1区医学 Q1 OBSTETRICS & GYNECOLOGY

Bjog-An International Journal of Obstetrics and Gynaecology Pub Date : 2024-12-17 DOI:10.1111/1471-0528.18026

Xin Li, Yixin Li, Hexiang Peng, Mengying Wang, Yuqi Liu, Tao Wu, Qing Xue

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引用次数: 0

Abstract

Objectives

To investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) pre-treatment on the clinical outcomes of fresh and frozen embryo transfers (ETs and FETs, respectively) in infertile patients with adenomyosis.

Design

Retrospective cohort study with literature review.

Setting

Peking University First Hospital.

Population

We analysed 413 cycles of 369 women with adenomyosis who underwent ETs or FETs.

Methods

We performed logistic regression analysis and meta-analysis to assess the association of GnRHa pre-treatment with the clinical outcomes of ETs and FETs.

Main Outcome Measures

The live birth rate (LBR) was compared between patients with and without GnRHa pre-treatment.

Results

The LBR was higher in the GnRHa pre-treatment group than in the non-GnRHa pre-treatment group in ETs (41.27% vs. 24.32%, p = 0.034) and FETs (40.36% vs. 20.75%, p = 0.008). The odds of achieving a live birth of women with GnRHa pre-treatment were 2.65 times higher than that of those without (95% CI: 1.19–5.92, p = 0.017) after adjusting for confounders in ETs. Similarly, the adjusted odds ratio (OR) was 2.43 (95% CI: 1.10–5.40, p = 0.029) in FETs. For the meta-analysis, eight studies met the inclusion criteria; however, only six reported the adjusted ORs. Combination of these six adjusted ORs with our results revealed that the GnRHa pre-treatment group had higher LBRs than the non-GnRHa pre-treatment group (ET: OR 1.71, 95% CI: 1.30–2.26, FET: OR 2.61, 95% CI: 1.52–4.49).

Conclusions

In women with adenomyosis, GnRHa pre-treatment may be beneficial for LBRs following both ETs and FETs.

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促性腺激素释放激素激动剂预处理对子宫腺肌症女性新鲜和冷冻胚胎移植结局的影响：一项回顾性队列研究并文献综述

目的：研究促性腺激素释放激素激动剂（GnRHa）预处理对子宫腺肌症不孕患者新鲜胚胎移植（ET）和冷冻胚胎移植（FET）临床结果的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bjog-An International Journal of Obstetrics and Gynaecology 医学-妇产科学

CiteScore

10.90

自引率

5.20%

发文量

345

审稿时长

3-6 weeks

期刊介绍： BJOG is an editorially independent publication owned by the Royal College of Obstetricians and Gynaecologists (RCOG). The Journal publishes original, peer-reviewed work in all areas of obstetrics and gynaecology, including contraception, urogynaecology, fertility, oncology and clinical practice. Its aim is to publish the highest quality medical research in women''s health, worldwide.