MeCP2 goes into unmethylated territories

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2024-12-17 DOI:10.1038/s41593-024-01846-6

Jun Young Sonn, Huda Y. Zoghbi

引用次数: 0

Abstract

Methyl-CpG-binding protein 2 (MeCP2) is a chromatin regulator whose loss of function causes Rett syndrome. It has been unclear how the gene-expression changes caused by loss of MeCP2 relate to the protein’s DNA-binding sites. New work uses the ‘CUT&RUN’ technique to identify DNA-binding sites that are largely devoid of methylation — a modification known to recruit MeCP2 to DNA.

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MeCP2 进入未甲基化区域

甲基-CpG结合蛋白2（MeCP2）是一种染色质调节因子，其功能缺失会导致Rett综合征。目前还不清楚MeCP2缺失导致的基因表达变化与该蛋白的DNA结合位点有何关系。新研究利用 "CUT&RUN "技术鉴定了大部分没有甲基化的DNA结合位点--甲基化是一种已知能将MeCP2招募到DNA上的修饰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.