The striatum is an early, accurate indicator of amyloid burden using [ ¹¹ C]PiB in Down syndrome: comparison of two radiotracers.

medRxiv : the preprint server for health sciences Pub Date : 2024-12-06 DOI:10.1101/2024.12.04.24318526

Max McLachlan, Brecca Bettcher, Andrew McVea, Alexandra DiFillipo, Matthew Zammit, Lisette LeMerise, Jeremy Rouanet, Julie Price, Dana Tudorascu, Charles Laymon, David Keator, Patrick Lao, Adam M Brickman, Tim Fryer, Sigan Hartley, Beau M Ances, Sterling Johnson, Tobey Betthauser, Charles K Stone, Shahid Zaman, Benjamin Handen, Elizabeth Head, Mark Mapstone, Bradley T Christian

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Abstract

Introduction: Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [ ¹¹ C]PiB PET imaging, which has not been replicated with [ ¹⁸ F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.

Methods: Longitudinal PiB (n=175 participants) and FBP (n=92 participants) data from the Alzheimer Biomarkers Consortium-Down Syndrome were used to measure cortical and striatal binding. Generalized temporal models for cortical and striatal amyloid accumulation were created using the sampled iterative local approximation (SILA) method.

Results: PiB demonstrated greater striatal-to-cortical ratios than FBP. SILA analysis revealed striatal amyloid burden occurs 3.40 (2.39) years earlier than the cortex in PiB. There was no difference between the cortex and striatum in FBP.

Discussion: Among adults with Down syndrome, the striatum consistently accumulates amyloid earlier than the cortex when measured with PiB. This suggests the striatum is more sensitive to the onset of PiB PET-detectable amyloid in Down syndrome.

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使用[11 C]PiB 检测唐氏综合征患者纹状体是淀粉样蛋白负荷的早期准确指标：两种放射性同位素的比较。

简介：成人唐氏综合征患者的[11 C]PiB PET成像显示纹状体首先出现淀粉样蛋白聚集，而[18 F]氟贝他匹(FBP)尚未证实这一点。早期纹状体积聚尚未与整体皮质测量进行时间量化：方法：使用阿尔茨海默生物标记物联合会-唐氏综合征的纵向 PiB（175 名参与者）和 FBP（92 名参与者）数据来测量皮质和纹状体结合。使用采样迭代局部逼近（SILA）方法建立了皮质和纹状体淀粉样蛋白积累的广义时间模型：结果：与 FBP 相比，PiB 显示出更大的纹状体与皮质比率。SILA 分析显示，在 PiB 中，纹状体淀粉样蛋白负荷比皮质早出现 3.40（2.39）年。讨论：讨论：在患有唐氏综合征的成人中，用PiB测量纹状体时，纹状体的淀粉样蛋白累积始终早于大脑皮层。这表明纹状体对唐氏综合征患者开始出现 PiB PET 可检测到的淀粉样蛋白更为敏感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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medRxiv : the preprint server for health sciences

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