Neonatal survival rate after expectant management of periviable preterm premature rupture of membranes at gestational age 15-23+6 weeks.

Abstract

Objective: To assess the neonatal survival rates, maternal complications, neonatal complications, and factors associated with survival rates following periviable premature rupture of membranes (PROM) between 15 and 23⁺⁶ weeks of gestation.

Materials and methods: The retrospective study included patients with periviable PROM between 15 and 23⁺⁶ weeks of gestation from January 1, 2008, to December 31, 2022. Multivariate regression analysis was performed to identify factors influencing neonatal survival.

Results: A total of 71 cases of periviable PROM between 15 and 23⁺⁶ weeks of gestation were included in the study, and the neonatal survival rate was found to be 26.8%. Maternal complications occurred in 59.2% of cases. Of the 19 surviving newborns, 89.5% experienced neonatal complications. Univariate analysis showed that gestational age at delivery, duration of latency and antenatal steroid administration were the factors significantly associated with increased survival rates after periviable PROM before 24 weeks of gestation.

Conclusion: The survival rate of periviable PROM between 15 and 23⁺⁶ weeks of gestation was 26.8% with neonatal complications of 89.5%. This information may be useful for counseling pregnant women experiencing periviable PROM.