Melissa Vos, Rujia Wang, Nanda N J Rommelse, Harold Snieder, Henrik Larsson, Catharina A Hartman
{"title":"Familial co-aggregation and shared familiality among neurodevelopmental problems and with aggressive behavior, depression, anxiety, and substance use.","authors":"Melissa Vos, Rujia Wang, Nanda N J Rommelse, Harold Snieder, Henrik Larsson, Catharina A Hartman","doi":"10.1017/S003329172400309X","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To refine the knowledge on familial transmission, we examined the (shared) familial components among neurodevelopmental problems (i.e. two attention-deficit/hyperactivity-impulsivity disorder [ADHD] and six autism spectrum disorder [ASD] subdomains) and with aggressive behavior, depression, anxiety, and substance use.</p><p><strong>Methods: </strong>Data were obtained from a cross-sectional study encompassing 37 688 participants across three generations from the general population. ADHD subdomains, ASD subdomains, aggressive behavior, depression, anxiety, and substance use were assessed. To evaluate familial (co-)aggregation, recurrence risk ratios (<i>λ</i><sub>R</sub>) were estimated using Cox proportional hazards models. The (shared) familiality (<i>f</i><sup>2</sup>), which is closely related to (shared) heritability, was assessed using residual maximum likelihood-based variance decomposition methods. All analyses were adjusted for sex, age, and age<sup>2</sup>.</p><p><strong>Results: </strong>The familial aggregation and familiality of neurodevelopmental problems were moderate (<i>λ</i><sub>R</sub> = 2.40-4.04; <i>f</i><sup>2</sup> = 0.22-0.39). The familial co-aggregation and shared familiality among neurodevelopmental problems (<i>λ</i><sub>R</sub> = 1.39-2.56; <i>r<sub>F</sub></i> = 0.52-0.94), and with aggressive behavior (<i>λ</i><sub>R</sub> = 1.79-2.56; <i>r<sub>F</sub></i> = 0.60-0.78), depression (<i>λ</i><sub>R</sub> = 1.45-2.29; <i>r<sub>F</sub></i> = 0.43-0.76), and anxiety (<i>λ</i><sub>R</sub> = 1.44-2.31; <i>r<sub>F</sub></i> = 0.62-0.84) were substantial. The familial co-aggregation and shared familiality between all neurodevelopmental problems and all types of substance use were weak (<i>λ</i><sub>R</sub> = 0.53-1.57; <i>r<sub>F</sub></i> = -0.06-0.35).</p><p><strong>Conclusions: </strong>Neurodevelopmental problems belonging to the same disorder were more akin than cross-disorder problems. That said, there is a clear (shared) familial component to neurodevelopmental problems, in part shared with other psychiatric problems (except for substance use). This suggests that neurodevelopmental disorders, disruptive behavior disorders, and internalizing disorders share genetic and environmental risk factors.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":" ","pages":"1-13"},"PeriodicalIF":5.9000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychological Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S003329172400309X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To refine the knowledge on familial transmission, we examined the (shared) familial components among neurodevelopmental problems (i.e. two attention-deficit/hyperactivity-impulsivity disorder [ADHD] and six autism spectrum disorder [ASD] subdomains) and with aggressive behavior, depression, anxiety, and substance use.
Methods: Data were obtained from a cross-sectional study encompassing 37 688 participants across three generations from the general population. ADHD subdomains, ASD subdomains, aggressive behavior, depression, anxiety, and substance use were assessed. To evaluate familial (co-)aggregation, recurrence risk ratios (λR) were estimated using Cox proportional hazards models. The (shared) familiality (f2), which is closely related to (shared) heritability, was assessed using residual maximum likelihood-based variance decomposition methods. All analyses were adjusted for sex, age, and age2.
Results: The familial aggregation and familiality of neurodevelopmental problems were moderate (λR = 2.40-4.04; f2 = 0.22-0.39). The familial co-aggregation and shared familiality among neurodevelopmental problems (λR = 1.39-2.56; rF = 0.52-0.94), and with aggressive behavior (λR = 1.79-2.56; rF = 0.60-0.78), depression (λR = 1.45-2.29; rF = 0.43-0.76), and anxiety (λR = 1.44-2.31; rF = 0.62-0.84) were substantial. The familial co-aggregation and shared familiality between all neurodevelopmental problems and all types of substance use were weak (λR = 0.53-1.57; rF = -0.06-0.35).
Conclusions: Neurodevelopmental problems belonging to the same disorder were more akin than cross-disorder problems. That said, there is a clear (shared) familial component to neurodevelopmental problems, in part shared with other psychiatric problems (except for substance use). This suggests that neurodevelopmental disorders, disruptive behavior disorders, and internalizing disorders share genetic and environmental risk factors.
期刊介绍：
Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
