RB functions as a key regulator of senescence and tumor suppression

IF 12.1 1区医学 Q1 ONCOLOGY

Seminars in cancer biology Pub Date : 2025-02-01 DOI:10.1016/j.semcancer.2024.11.004

Minling Gao , Haiou Li , Jinfang Zhang

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引用次数: 0

Abstract

The Retinoblastoma (RB) protein is crucial for regulating gene transcription and chromatin remodeling, impacting cell cycle progression, cellular senescence, and tumorigenesis. Cellular senescence, characterized by irreversible growth arrest and phenotypic alterations, serves as a vital barrier against tumor progression and age-related diseases. RB is crucial in mediating senescence and tumor suppression by modulating the RB-E2F pathway and cross talking with other key senescence effectors such as p53 and p16^INK4a. The interplay between RB-mediated cell cycle arrest and cellular senescence offers critical insights into tumorigenesis and potential therapeutic strategies. Leveraging RB-mediated senescence presents promising opportunities for cancer therapy, including novel approaches in tumor immunotherapy designed to enhance treatment efficacy. This review highlights recent advancements in the RB signaling pathway, focusing on its roles in cellular senescence and tumor suppression, and discusses its potential to improve tumor management and clinical outcomes.

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RB是衰老和肿瘤抑制的关键调节因子。

视网膜母细胞瘤（RB）蛋白在调节基因转录和染色质重塑、影响细胞周期进程、细胞衰老和肿瘤发生中起着至关重要的作用。细胞衰老，以不可逆的生长停滞和表型改变为特征，是对抗肿瘤进展和年龄相关疾病的重要屏障。RB通过调节RB- e2f通路并与其他关键的衰老效应因子如p53和p16INK4a相互作用，在介导衰老和肿瘤抑制中起着至关重要的作用。rb介导的细胞周期阻滞和细胞衰老之间的相互作用为肿瘤发生和潜在的治疗策略提供了重要的见解。利用rb介导的衰老为癌症治疗提供了有希望的机会，包括旨在提高治疗效果的肿瘤免疫治疗的新方法。本文综述了RB信号通路的最新进展，重点关注其在细胞衰老和肿瘤抑制中的作用，并讨论了其改善肿瘤管理和临床结果的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.