Labor Status at Delivery and Lung Function in Extremely Prematurely Born Young Adults.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2025-01-01 Epub Date: 2024-12-16 DOI:10.1002/ppul.27440

Sean Armstrong, Christopher Harris, Mohadeseh Kazemi, Alan Lunt, Janet Peacock, Anne Greenough

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引用次数: 0

Abstract

Background: There has been conflicting evidence regarding the impact of mode of delivery on respiratory outcomes in later childhood and adulthood. It is possible labor status, rather than mode of delivery, influences later respiratory morbidity. We hypothesized that extremely premature infants born to mothers in labor would have better lung function at follow-up than those born to mothers not in labor.

Methods: We reviewed data from the United Kingdom High-Frequency Oscillation Study. Lung function testing was performed on young people aged 16-18 years born before 29 weeks of gestation. Linear mixed models were used to adjust lung function for maternal and neonatal factors and for the clustering due to multiple births.

Results: One hundred and fifty subjects underwent lung function testing. Young adults born to mothers in labor had better mean Forced Expiratory Flow₇₅ (FEF₇₅) compared to those born to mothers not in labor (adjusted difference 0.50 [95% CI: 0.02, 0.99]). Similar significant differences were noted in FEF₅₀ (0.45 [-0.05, 0.85]), and FEF_25-75 (0.53 [0.05, 1.01]).

Conclusion: Our study demonstrates that amongst individuals born very prematurely, those whose mothers were in labor before delivery had better small airway function at 16-19 years of age.

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极早产青壮年分娩时的产程状况和肺功能。

背景：关于分娩方式对儿童后期和成年期呼吸结局的影响，有相互矛盾的证据。可能是分娩状态，而不是分娩方式，影响后来的呼吸道疾病。我们假设，在随访中，分娩母亲所生的极早产儿的肺功能比未分娩母亲所生的早产儿更好。方法：我们回顾了英国高频振荡研究的数据。肺功能测试是在怀孕29周前出生的16-18岁的年轻人中进行的。线性混合模型用于调整肺功能的产妇和新生儿因素和聚类由于多胎。结果：150名受试者进行了肺功能检查。分娩母亲所生的年轻人比未分娩母亲所生的年轻人平均用力呼气流量75 （FEF75）更好（调整差为0.50 [95% CI: 0.02, 0.99]）。FEF50（0.45[-0.05, 0.85]）和FEF25-75（0.53[0.05, 1.01]）也存在类似的显著差异。结论：我们的研究表明，在早产的个体中，那些母亲在分娩前分娩的人在16-19岁时具有更好的小气道功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.