Lipid droplet biogenesis in the ovary.

IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Reproductive Medicine and Biology Pub Date : 2024-12-15 eCollection Date: 2024-01-01 DOI:10.1002/rmb2.12618
Megumi Ibayashi, Satoshi Tsukamoto
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引用次数: 0

Abstract

Background: Lipid droplets (LDs) are organelles consisting of a central core of neutral lipids covered by a single layer of phospholipids and are found in most eukaryotic cells. Accumulating evidence suggests that LDs not only store neutral lipids but also coordinate with other organelles for lipid metabolism within cells.

Methods: This review focuses on the synthesis of LDs during follicular development and highlights the factors involved in the regulation of LD biogenesis within the ovary.

Main findings: In the mammalian ovary, the presence of LDs has long been recognized mainly by morphological analysis. However, their distribution in the ovary varies according to the region and cell type; for example, LDs are abundant in the medulla, which has a rich blood vessel network, in interstitial cells, which are the site of steroid production, and surrounding growing follicles, while they are poor in granulosa cells within follicles. LDs are also enriched in the corpus luteum after ovulation and massively accumulate in atretic follicles during follicular growth. Furthermore, LD synthesis is synchronized with angiogenesis during follicular development.

Conclusion: Addressing the functional link between LD biogenesis and angiogenesis is essential for understanding the molecular basis underlying LD biology, as well as the ovarian dysfunction with metabolic disorders.

卵巢中脂滴的生物生成
背景:脂滴(LDs)是一种细胞器,由一层磷脂覆盖的中性脂质的核心组成,存在于大多数真核细胞中。越来越多的证据表明,ld不仅储存中性脂质,而且还与细胞内的其他细胞器协调脂质代谢。方法:本文综述了卵泡发育过程中LD的合成,重点介绍了卵巢内LD生物发生的调控因素。主要发现:在哺乳动物卵巢中,ld的存在早已主要通过形态学分析得到确认。然而,它们在卵巢中的分布因区域和细胞类型而异;例如,ld在具有丰富血管网络的髓质、产生类固醇的间质细胞和生长卵泡周围中含量丰富,而在卵泡内的颗粒细胞中含量较少。排卵后的黄体也富含LDs,并在卵泡生长过程中大量积聚在闭锁卵泡中。此外,在卵泡发育过程中,LD合成与血管生成是同步的。结论:阐明LD生物发生与血管生成之间的功能联系,对于理解LD生物学的分子基础以及卵巢功能障碍伴代谢紊乱具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.70
自引率
5.90%
发文量
53
审稿时长
20 weeks
期刊介绍: Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.
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