Clinical value of serum miRNA-206 in pulmonary tuberculosis.

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2024-12-13 DOI:10.1016/j.jiac.2024.12.018

Wei Chu, Hongqiu Pan, Zhongting Fei, Tiantian Zhang

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引用次数: 0

Abstract

Objective: This study sought to investigate the diagnostic value and the effect of microRNA (miR)-206 on drug resistance in pulmonary tuberculosis (TB) patients.

Methods: This study included 88 TB patients (TB group) as study subjects, 80 healthy subjects as control 1 (Control group), and 85 latent TB infection (LTBI) patients as control 2 (LTBI group). The drug resistance of TB patients after standard anti-TB treatment was recorded. TB patients were assigned into the pan-sensitive and drug-resistance groups, with miR-206 level in drug-resistant TB patients analyzed. The correlation coefficients between inflammatory indicators (TNF-α, IgG, IL-4, IFN-γ, IP-10) and drug resistance in TB patients were analyzed, and the independent correlation between miR-206 levels and drug resistance was analyzed.

Results: Compared to the Control and LTBI groups, serum miR-206 and IP-10 were highly-expressed in TB group. The miR-206 levels positively correlated with IP-10 levels. miR-206 had potential diagnostic value for TB. Levels of TNF-α, IgG, IFN-γ, and IL-4 were elevated in TB group and positively-correlated with miR-206 levels. Moreover, miR-206 levels were higher in the Drug-resistance group than the pan-sensitive group. The low-expression group had a lower incidence of drug resistance than the high-expression group (χ² = 16.84, P < 0.0001). miR-206 was the most significant indicator affecting drug resistance in TB patients (β = 0.516, P = 0.013). miR-206 was an independent risk factor for drug resistance.

Conclusion: High miR-206 expression helps TB diagnosis and may predict drug-resistance incidence. miR-206 may be an independent risk factor for drug resistance in TB patients.

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研究目的本研究旨在探讨微RNA（miR）-206对肺结核（TB）患者耐药性的诊断价值和影响：研究对象包括 88 名肺结核患者（肺结核组）、80 名健康受试者作为对照 1（对照组）和 85 名潜伏肺结核感染（LTBI）患者作为对照 2（LTBI 组）。记录肺结核患者在接受标准抗结核治疗后的耐药性。将肺结核患者分为泛敏感组和耐药组，并分析耐药肺结核患者的 miR-206 水平。分析结核病患者炎症指标（TNF-α、IgG、IL-4、IFN-γ、IP-10）与耐药性的相关系数，并分析 miR-206 水平与耐药性的独立相关性：结果：与对照组和LTBI组相比，肺结核组血清miR-206和IP-10高表达。miR-206 对结核病有潜在的诊断价值。结核病组的 TNF-α、IgG、IFN-γ 和 IL-4 水平升高，并与 miR-206 水平呈正相关。此外，耐药组的 miR-206 水平高于泛敏感组。低表达组的耐药发生率低于高表达组（χ2 = 16.84，P < 0.0001），miR-206是影响肺结核患者耐药性最显著的指标（β = 0.516，P = 0.013）：miR-206的高表达有助于结核病的诊断，并可预测耐药性的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.