Mild hypohydration in healthy older adults increases pain-related brain activity without affecting pain perception: A single-blind study.

IF 3.3 3区 医学 Q1 PHYSIOLOGY
Thomas A Deshayes, Félix-Antoine Savoie, Timothée Pancrate, Antoine Jolicoeur Desroches, José A Morais, Pierre-Michel Bernier, Guillaume Léonard, Ivan L Simoneau, Eric D B Goulet
{"title":"Mild hypohydration in healthy older adults increases pain-related brain activity without affecting pain perception: A single-blind study.","authors":"Thomas A Deshayes, Félix-Antoine Savoie, Timothée Pancrate, Antoine Jolicoeur Desroches, José A Morais, Pierre-Michel Bernier, Guillaume Léonard, Ivan L Simoneau, Eric D B Goulet","doi":"10.1152/japplphysiol.00870.2024","DOIUrl":null,"url":null,"abstract":"<p><p>Understanding how hydration status influences pain perception is particularly important in older adults, as both dehydration and pain are prevalent in this population. Ten individuals (70 ± 4 years) completed two randomized and counterbalanced trials. They were exposed to passive heat until they lost 1% body mass through sweat and urine (~ 100 min), with the loss either unreplaced (sham infusion, HYPO) or fully replaced via 0.45% saline infusion (EUH). Nociceptive electrical stimulation was applied to the sural nerve (1) before heat exposure (baseline), (2) 60 min following hydration manipulation (R60, ~ 160 min after baseline); (3) after mouth rinsing with water (MR, ~ 170 min after baseline) and; (4) following water ingestion (ING, ~ 185 min after baseline). Pain-related event-related potentials were assessed using electroencephalography (EEG) at R60, MR, and ING. After hydration manipulation, body mass loss and plasma osmolality were greater, and plasma volumes was lower in HYPO compared to EUH, although thirst did not differ between the conditions. There were no differences between the two conditions regarding pain intensity and unpleasantness. Still, EEG analyses revealed that the peak-to-peak amplitude of the pain-related N200-P300 potential (~ 136 - 310 ms) was significantly greater in HYPO compared to EUH (<i>p</i> = 0.036), and significantly greater in R60 compared to both MR (<i>p</i> = 0.01) and ING (<i>p</i> = 0.03), either with HYPO and EUH. These results suggest that mild hypohydration in healthy older adults may influence some neurophysiological processes related to nociception without significantly affecting pain perception.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of applied physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/japplphysiol.00870.2024","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Understanding how hydration status influences pain perception is particularly important in older adults, as both dehydration and pain are prevalent in this population. Ten individuals (70 ± 4 years) completed two randomized and counterbalanced trials. They were exposed to passive heat until they lost 1% body mass through sweat and urine (~ 100 min), with the loss either unreplaced (sham infusion, HYPO) or fully replaced via 0.45% saline infusion (EUH). Nociceptive electrical stimulation was applied to the sural nerve (1) before heat exposure (baseline), (2) 60 min following hydration manipulation (R60, ~ 160 min after baseline); (3) after mouth rinsing with water (MR, ~ 170 min after baseline) and; (4) following water ingestion (ING, ~ 185 min after baseline). Pain-related event-related potentials were assessed using electroencephalography (EEG) at R60, MR, and ING. After hydration manipulation, body mass loss and plasma osmolality were greater, and plasma volumes was lower in HYPO compared to EUH, although thirst did not differ between the conditions. There were no differences between the two conditions regarding pain intensity and unpleasantness. Still, EEG analyses revealed that the peak-to-peak amplitude of the pain-related N200-P300 potential (~ 136 - 310 ms) was significantly greater in HYPO compared to EUH (p = 0.036), and significantly greater in R60 compared to both MR (p = 0.01) and ING (p = 0.03), either with HYPO and EUH. These results suggest that mild hypohydration in healthy older adults may influence some neurophysiological processes related to nociception without significantly affecting pain perception.

健康老年人轻度缺水会增加与疼痛相关的大脑活动,但不会影响疼痛感觉:单盲研究。
了解水合状态如何影响疼痛感对老年人尤为重要,因为脱水和疼痛在这一人群中都很普遍。十名受试者(70 ± 4 岁)完成了两项随机平衡试验。他们暴露在被动热环境中,直到他们通过出汗和尿液流失 1%的体重(约 100 分钟),流失的水分要么得不到补充(假输注,HYPO),要么通过输注 0.45% 的生理盐水得到完全补充(EUH)。对硬神经进行痛觉电刺激:(1)热暴露前(基线);(2)水合操作 60 分钟后(R60,基线后约 160 分钟);(3)用水漱口后(MR,基线后约 170 分钟);(4)进水后(ING,基线后约 185 分钟)。在 R60、MR 和 ING 时使用脑电图(EEG)评估与疼痛相关的事件相关电位。水合操作后,与 EUH 相比,HYPO 的体质量损失和血浆渗透压更高,血浆容量更低,但口渴程度在两种条件下没有差异。两种情况下的疼痛强度和难受程度没有差异。然而,脑电图分析表明,HYPO 与 EUH 相比,与疼痛相关的 N200-P300 电位(约 136 - 310 ms)的峰-峰振幅显著增大(p = 0.036);与 MR(p = 0.01)和 ING(p = 0.03)相比,R60 与 HYPO 和 EUH 相比,均显著增大。这些结果表明,健康老年人的轻度缺水可能会影响一些与痛觉相关的神经生理过程,但不会明显影响痛觉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.00
自引率
9.10%
发文量
296
审稿时长
2-4 weeks
期刊介绍: The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信