CEACAM1 in vascular homeostasis and inflammation

IF 4.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

European Journal of Clinical Investigation Pub Date : 2024-12-14 DOI:10.1111/eci.14345

Lisa Götz, Uwe Rueckschloss, Süleyman Ergün, Florian Kleefeldt

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引用次数: 0

Abstract

Introduction

The glycoprotein Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 (CEACAM1), also known as CD66a, is a member of the immunoglobulin superfamily. It is expressed in a variety of tissues including epithelial, immune, as well as endothelial cells, and is crucial to diverse physiological and pathological mechanisms. This review aims to provide a comprehensive understanding of CEACAM1's multifaceted roles in vascular biology and inflammatory processes.

Methods

Directed literature research was conducted using databases, such as PubMed, and relevant studies were categorized based on the physiological effects of CEACAM1.

Results

CEACAM1 plays a pivotal role in vascular homeostasis, particularly influencing the formation, maturation, and aging of blood vessels, as well as the endothelial barrier function. It supports endothelium-dependent vasodilation and nitric oxide formation, thus promoting vascular integrity and regulating blood pressure. Additionally, CEACAM1 is of emerging importance to vascular inflammation and its potential clinical consequences.

Conclusion

CEACAM1 is a crucial regulator of vascular homeostasis and inflammation with significant implications for cardiovascular health. Despite the lack of understanding of tissue-specific modulation and isoform-dependent mechanisms, CEACAM1 could be a promising therapeutic target for the prevention of cardiovascular disease in the future.

Abstract Image

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CEACAM1在血管稳态和炎症中的作用。

糖蛋白癌胚抗原相关细胞粘附分子1 (CEACAM1)，也称为CD66a，是免疫球蛋白超家族的一员。它在多种组织中表达，包括上皮细胞、免疫细胞和内皮细胞，对多种生理和病理机制至关重要。本文旨在全面了解CEACAM1在血管生物学和炎症过程中的多方面作用。方法：利用PubMed等数据库进行定向文献研究，并根据CEACAM1的生理作用对相关研究进行分类。结果：CEACAM1在血管稳态中起关键作用，尤其影响血管的形成、成熟、老化以及内皮屏障功能。它支持内皮依赖性血管扩张和一氧化氮的形成，从而促进血管完整性和调节血压。此外，CEACAM1在血管炎症及其潜在临床后果中具有重要意义。结论：CEACAM1是血管稳态和炎症的重要调节因子，对心血管健康具有重要意义。尽管缺乏对组织特异性调节和同型依赖机制的了解，但CEACAM1可能是未来预防心血管疾病的有希望的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Clinical Investigation 医学-医学：内科

CiteScore

9.50

自引率

3.60%

发文量

192

审稿时长

1 months

期刊介绍： EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.