Unraveling neural adaptation to vocal and non-vocal sounds in autism.

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-12-11 DOI:10.1016/j.clinph.2024.12.003

Annabelle Merchie, Frédérique Bonnet-Brilhault, Carles Escera, Emmanuelle Houy-Durand, Marie Gomot

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引用次数: 0

Abstract

Objective: Autism is linked to a strong need for sameness and difficulties in social communication, associated with atypical brain responses to voices and changes. This study aimed to characterize neural adaptation in autistic adults using a Roving paradigm and assess how vocal vs. non-vocal, as well as neutral vs. emotional sounds, influence this adaptation.

Methods: Neural adaptation was measured in 20 autistic and 20 non-autistic adults using a Roving paradigm, where sounds were repeated 4, 8, or 14 times. Neural responses and Repetition Positivity (RP) amplitudes were analyzed as indices of adaptation.

Results: RP amplitudes showed no significant differences between groups for vocal or non-vocal sounds, but adaptation dynamics varied. Non-autistic adults adapted more quickly to non-vocal (5-8 repetitions) compared to vocal sounds (12-14 repetitions). In contrast, autistic adults adapt faster to vocal than to non-vocal sounds. Moreover emotional prosodic content influenced RP amplitude in autistic adults only, suggesting heightened sensitivity to emotional cues in social contexts.

Conclusions: The study highlights how atypical neural adaptation in autism how emotional content impacts social communication deficits. These insights enhance understanding of autism-related adaptation challenges.

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目的：自闭症与对同一性的强烈需求和社会交流困难有关，与大脑对声音和变化的非典型反应有关。本研究旨在利用巡回范式描述自闭症成人的神经适应性，并评估发声与不发声、中性声音与情绪化声音对这种适应性的影响：方法：使用巡回范式测量了 20 名自闭症成人和 20 名非自闭症成人的神经适应性，其中声音重复 4、8 或 14 次。分析神经反应和重复正向性（RP）振幅作为适应指数：结果：对于发声或不发声的声音，各组之间的 RP 振幅无明显差异，但适应动态却各不相同。与发声（12-14 次重复）相比，非自闭症成人对非发声（5-8 次重复）的适应更快。相比之下，自闭症成人对有声声音的适应快于无声声音。此外，情绪性的前音内容只影响自闭症成人的 RP 幅值，这表明他们对社会环境中的情绪线索更加敏感：该研究强调了自闭症患者的非典型神经适应如何影响情感内容对社会交流障碍的影响。这些见解加深了人们对自闭症相关适应挑战的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.