Portulaca Oleracea L. as a Potential Therapeutic Drug Intervention in Ulcerative Colitis: Mechanisms of Action and Clinical Studies.

IF 4.7 2区医学 Q1 CHEMISTRY, MEDICINAL

Drug Design, Development and Therapy Pub Date : 2024-12-11 eCollection Date: 2024-01-01 DOI:10.2147/DDDT.S486407

Xiao-Yan Liu, Zi-Xuan Liu, Wei-Wei Tan, Wei-Bing Zhang, Ya-Li Zhang, Lie Zheng, Ren-Ye Que, Hong-Zhu Wen, Yan-Cheng Dai

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引用次数: 0

Abstract

Portulaca oleracea L. (POL) has a long history of medicinal use worldwide, and numerous clinical and experimental studies demonstrated the therapeutic effects of POL and its active ingredients in the treatment of Ulcerative colitis (UC). In this review, we summarized the underlying mechanisms and roles of POL in UC treatment based on experimental and clinical studies. The research articles cited in this study were obtained by employing specific keywords, such as "purslane", "IBD", "UC", "inflammation", "gut microbiota", and "intestinal barrier", in PubMed, Web of Science, Google Scholar, and China National Knowledge Infrastructure databases. Clinical studies found that both POL monotherapy and POL traditional Chinese medicine compound are effective in treating UC. Meanwhile, experimental studies found that POL intervenes in UC by regulating intestinal flora, repairing mucosal barrier, and regulating immune response. Increasing evidence suggests the therapeutic potential of POL in UC treatment.

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作为溃疡性结肠炎潜在治疗药物的马齿苋：作用机制和临床研究。

马齿苋（porulaca oleracea L.， POL）在世界范围内具有悠久的药用历史，大量的临床和实验研究证明了POL及其有效成分对溃疡性结肠炎（UC）的治疗作用。在这篇综述中，我们根据实验和临床研究总结了POL在UC治疗中的潜在机制和作用。本研究引用的研究文章均采用PubMed、Web of Science、谷歌Scholar和中国国家知识基础设施数据库中“马齿苋”、“IBD”、“UC”、“炎症”、“肠道微生物群”、“肠道屏障”等特定关键词获取。临床研究发现，POL单药治疗和POL中药复方治疗UC均有效。同时，实验研究发现，POL通过调节肠道菌群、修复粘膜屏障、调节免疫应答等方式干预UC的发生。越来越多的证据表明，POL在UC治疗中的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.