Influence of Implant Component Materials on Peri-Implant Soft Tissue Healing: A Comparative Histological and Immunohistochemical Study in Humans.

IF 4.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research Pub Date : 2024-12-16 DOI:10.1111/clr.14391

Lemmy Liegeois, Manon Borie, Geoffrey Lecloux, Dorien Van Hede, France Lambert

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Abstract

Background: Recently, the importance of peri-implant soft tissue integration quality has been recognised as an essential factor in the long-term success of dental implant rehabilitation.

Aim: The aim of this study was to explore the influence of three materials commonly used in implant dentistry, namely titanium (Ti), dental adhesive resin (Re) and polyetheretherketone (PEEK), on the peri-implant soft tissues.

Methods: In this clinical randomised comparative study, 37 bone-level implants were placed, and experimental transmucosal healing abutments made of different materials were randomly assigned to each implant. These abutments were removed together with the surrounding soft tissues after 8 weeks. Immunohistochemical analyses were performed to determine the presence and localisation of different immune cells. In addition, clinical and radiographic data were collected and peri-implant bone remodeling was assessed.

Results: Compared to the Ti and PEEK groups, Re abutments revealed a higher infiltration of macrophages in the connective tissue (p = 0.04) and neutrophils in the adjacent epithelium (p = 0.03). In the Re abutments, peri-implant bone remodeling was higher compared to the other groups (p = 0.01).

Conclusion: The use of resin material as a transmucosal healing abutment should be carefully considered as it was associated with a higher presence of inflammatory cells at 8 weeks post-implantation as well as superior bone remodeling compared to PEEK and Ti.

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种植体组件材料对种植体周围软组织愈合的影响：人体组织学和免疫组织化学比较研究

背景：目的：本研究旨在探讨种植牙常用的三种材料，即钛（Ti）、牙科粘接树脂（Re）和聚醚醚酮（PEEK）对种植体周围软组织的影响：在这项临床随机对比研究中，共植入了 37 个骨水平种植体，并在每个种植体上随机分配了由不同材料制成的实验性经粘膜愈合基台。8 周后，将这些基台和周围软组织一起取出。进行免疫组化分析以确定不同免疫细胞的存在和定位。此外，还收集了临床和放射学数据，并评估了种植体周围的骨重塑情况：结果：与钛基台和 PEEK 基台相比，Re 基台在结缔组织中显示出更高的巨噬细胞浸润（p = 0.04），在邻近上皮中显示出更高的中性粒细胞浸润（p = 0.03）。与其他组相比，Re基台的种植体周围骨重塑程度更高（p = 0.01）：结论：使用树脂材料作为经粘膜愈合基台应慎重考虑，因为与PEEK材料和钛材料相比，树脂材料在种植体植入后8周的炎性细胞含量更高，骨重塑效果更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Oral Implants Research 医学-工程：生物医学

CiteScore

7.70

自引率

11.60%

发文量

149

审稿时长

3 months

期刊介绍： Clinical Oral Implants Research conveys scientific progress in the field of implant dentistry and its related areas to clinicians, teachers and researchers concerned with the application of this information for the benefit of patients in need of oral implants. The journal addresses itself to clinicians, general practitioners, periodontists, oral and maxillofacial surgeons and prosthodontists, as well as to teachers, academicians and scholars involved in the education of professionals and in the scientific promotion of the field of implant dentistry.