Comparison of Hematological Parameters and the Associated Factors Among Women with and without Breast Cancer: A Case-Control Study.

IF 3.3 4区医学 Q2 ONCOLOGY

Breast Cancer : Targets and Therapy Pub Date : 2024-12-10 eCollection Date: 2024-01-01 DOI:10.2147/BCTT.S497313

Abdul Baset Abbas, Shima Al-Gamei, AmatAlraheem Naser, Ahlam Al-Oqab, Khawla Alduhami, Manal Al-Sabri, Asmahan Al-Qasem, Mona Gharama, Amal Mohammed, Shuaib Ahmed, Malek Al-Glal

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Abstract

Background: Breast cancer (BC) is the most popular and dangerous cancer, with a high mortality rate. Hematological parameters are often used in routine diagnosis of numerous disorders. Therefore, the study aimed to evaluate hematological parameters amongst women with and without BC.

Methodology: Briefly, 200 blood samples (100 cases and 100 controls) were collected at Life Center of Breast Cancer Control, Ibb City, Yemen. The whole blood samples were tested immediately for complete blood count (CBC) parameters. Socio-demographic and reproductive characteristics were collected by using a standardized questionnaire. Kolmogorov-Smirnov test, Unpaired t-test, Mann-Whitney test, Fisher's exact test and chi-square test for trends were calculated using GraphPad Prism 8.0.1. P-values ≤0.05 were statistically significant.

Results: The mean and standard deviation (SD) revealed significant differences between BC group and the healthy control group attributed to the variables of age (P<0.0001), weight (P<0.0001), residence (P=0.0218), employment state (P<0.0001), economic state (P=0.0003), education levels (P<0.0001), regular exercise (P<0.0001) and a strict diet (P<0.0008). Marital state, marital age, number of births, and use of contraceptives demonstrated statistical significance (P<0.0001, P=0.0008, P=0.0009, and P<0.0001, respectively). Additionally, Hb, RBCs, WBCs count, neutrophils, lymphocytes and monocytes displayed significant differences (P=0.0393, P=0.0045, P=0.0327, P=0.0441, P=0.0098 and P<0.0001, respectively).

Conclusion: Hb, RBCs, WBCs, neutrophils, lymphocytes, monocytes and other parameters scored high points of evidence for BC surveillance. Further studies are required to evaluate hematological parameter differences and biochemical parameters after or during chemotherapy or mastectomy.

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患有和未患有乳腺癌的妇女血液学参数及其相关因素的比较：病例对照研究

背景：乳腺癌（BC）是最常见、最危险的癌症，死亡率很高。血液学参数通常用于多种疾病的常规诊断。因此，本研究旨在评估患有和未患有乳腺癌的妇女的血液学参数：简言之，研究人员在也门伊卜市乳腺癌控制生命中心采集了 200 份血液样本（100 份病例和 100 份对照）。全血样本立即进行全血细胞计数（CBC）参数检测。通过标准化问卷收集社会人口学特征和生殖特征。使用 GraphPad Prism 8.0.1 进行了 Kolmogorov-Smirnov 检验、非配对 t 检验、Mann-Whitney 检验、费雪精确检验和趋势的卡方检验。P值≤0.05为差异有统计学意义：平均值和标准差（SD）显示，BC 组与健康对照组在年龄（PPP=0.0218）、就业状况（PP=0.0003）、教育水平（PPPPP=0.0008、P=0.0009 和 PP=0.0393、P=0.0045、P=0.0327、P=0.0441、P=0.0098 和 PConclusion）等变量上存在显著差异：血红蛋白、红细胞、白细胞、中性粒细胞、淋巴细胞、单核细胞和其他参数为 BC 监测提供了高分证据。在化疗或乳房切除术后或化疗期间，需要进一步研究评估血液参数差异和生化参数。

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