General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors.

IF 5.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Pub Date : 2024-12-10 DOI:10.1016/j.breast.2024.103857

Ji Soo Kim, Jihun Song, Seulggie Choi, Sang Min Park

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引用次数: 0

Abstract

Background: To assess the association between discrepancies between general obesity and abdominal obesity and the risk of subsequent cardiovascular disease (CVD), including stroke, in breast cancer survivors.

Methods: We undertook a retrospective cohort study using data from the National Health Insurance Service of South Korea. Among 72,174 5-year breast cancer survivors aged 40 years and above, body mass index (BMI) and waist circumference (WC) were used to determine obesity status. Cox proportional hazards models were used to evaluate the association of obesity and risk of CVD, including stroke.

Results: Compared to those with normal WC and BMI, those who were overweight without abdominal obesity, had abdominal obesity only, and overweight with abdominal obesity, had higher risks of CVD [aHR(95 % CI) 1.23(1.02-1.48), 1.51(1.16-1.95), and 1.55(1.31-1.75), respectively] and total stroke [1.09(0.86-1.38), 1.63(1.20-2.23), and 1.40(1.17-1.68), respectively]. Compared to those overweight, those with abdominal obesity only had a significantly higher risk of ischemic stroke [2.04(1.14-3.65)].

Conclusions: Breast cancer survivors with higher BMI and/or abdominal obesity were associated with an elevated risk of CVD, including stroke.

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乳腺癌五年期幸存者的全身肥胖、腹部肥胖和包括中风在内的心血管疾病风险。

背景：评估乳腺癌幸存者全身肥胖和腹部肥胖之间的差异与继发心血管疾病（包括中风）风险之间的关系：目的：评估乳腺癌幸存者全身肥胖和腹部肥胖之间的差异与包括中风在内的后续心血管疾病（CVD）风险之间的关系：我们利用韩国国民健康保险服务的数据进行了一项回顾性队列研究。在 72174 名年龄在 40 岁及以上的 5 年期乳腺癌幸存者中，我们使用体重指数（BMI）和腰围（WC）来确定肥胖状况。采用 Cox 比例危险模型评估肥胖与心血管疾病（包括中风）风险的关系：结果：与腹围和体重指数正常者相比，无腹部肥胖的超重者、仅有腹部肥胖者和有腹部肥胖的超重者患心血管疾病的风险更高[aHR(95 % CI) 1.分别为 1.23（1.02-1.48）、1.51（1.16-1.95）和 1.55（1.31-1.75））]和总中风[分别为 1.09（0.86-1.38）、1.63（1.20-2.23）和 1.40（1.17-1.68）]。与超重者相比，腹部肥胖者发生缺血性中风的风险明显更高[2.04(1.14-3.65)]：结论：BMI 较高和/或腹部肥胖的乳腺癌幸存者罹患心血管疾病（包括中风）的风险较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast 医学-妇产科学

CiteScore

8.70

自引率

2.60%

发文量

165

审稿时长

59 days

期刊介绍： The Breast is an international, multidisciplinary journal for researchers and clinicians, which focuses on translational and clinical research for the advancement of breast cancer prevention, diagnosis and treatment of all stages.