Oxidized high-density lipoprotein and low-density lipoprotein in adolescents with obesity and metabolic dysfunction-associated steatotic liver disease.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2025-02-01 Epub Date: 2024-12-16 DOI:10.1111/ijpo.13194

Alyssa M Bartlett, Ali M Boone, Jordan A Bays, Youngsil Kim, Sirish K Palle, Kevin R Short

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引用次数: 0

Abstract

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly common in the pediatric population and may increase risk for developing cardiovascular disease (CVD) in people with MASLD. Oxidized high-density lipoprotein (oxHDL) and oxidized low-density lipoprotein (oxLDL) are modified, pro-atherosclerotic lipoproteins that are increased in adults with MASLD and CVD but have not been reported in adolescents with MASLD.

Purpose: To determine if oxLDL and oxHDL are increased in adolescents with MASLD.

Methods: Fasting oxHDL and oxLDL were measured in adolescents (11-20 years) with obesity and biopsy-confirmed MASLD (n = 47), and peers without MASLD but with obesity (Ob; n = 28), or normal weight (NW; n = 29).

Results: oxHDL was 27% higher (p < 0.05) in the MASLD group (mean ± SD: 11.9 ± 4.7 ng/mL) compared to the Ob group (9.3 ± 3.7 ng/mL, p < 0.05) but only 7% higher than the NW group (11.1 ± 3.8 ng/mL, p > 0.05). However, HDL-C was 19% and 32% lower in the MASLD group than in the Ob and NW groups, respectively. Thus, oxHDL/HDL-C ratio was 55% and 66% higher in MASLD compared to the Ob group (p < 0.004) and the NW group (p < 0.001), respectively. oxLDL (52.4 ± 16.0, 46.7 ± 10.1 and 47.1 ± 15.2 U/L for MASLD, Ob and NW, respectively), LDL-C and the oxLDL/LDL-C ratio did not differ among groups.

Conclusions: The elevated oxHDL and oxHDL/HDL-C in adolescents with MASLD compared to peers with Ob or NW suggests that there is some oxidative stress in MASLD independent of obesity and potential for increased CVD risk in the future.

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氧化高密度脂蛋白和低密度脂蛋白与青少年肥胖和代谢功能障碍相关的脂肪变性肝病

背景：代谢功能障碍相关的脂肪变性肝病（MASLD）在儿科人群中越来越常见，并可能增加MASLD患者发生心血管疾病（CVD）的风险。氧化高密度脂蛋白（oxHDL）和氧化低密度脂蛋白（oxLDL）是经过修饰的促动脉粥样硬化脂蛋白，在成人MASLD和CVD患者中升高，但在青少年MASLD患者中未见报道。目的：确定青少年MASLD患者oxLDL和oxHDL是否升高。方法：对肥胖和活检证实的MASLD青少年（n = 47）和无MASLD但肥胖的同龄人（n = 47）进行空腹oxHDL和oxLDL测定。n = 28)或正常体重(NW；n = 29)。结果：oxHDL升高27% （p < 0.05）。然而，MASLD组的HDL-C分别比Ob组和NW组低19%和32%。因此，与Ob组相比，MASLD的oxHDL/HDL-C比值分别高出55%和66% (p结论：与Ob或NW组相比，MASLD青少年的oxHDL和oxHDL/HDL-C升高表明MASLD中存在一些独立于肥胖的氧化应激，并可能增加未来心血管疾病的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.