Assessment and Prediction of Salivary Gland Function After Head and Neck Radiotherapy: A Systematic Review

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2024-12-16 DOI:10.1002/cam4.70494

J. Le Guevelou, X. Palard-Novello, E. Kammerer, M. Baty, M. Perazzi, A. Larnaudie, R. De Crevoisier, J. Castelli

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引用次数: 0

Abstract

Background

Modern imaging techniques with magnetic resonance imaging (MRI) or positron emission tomography/computed tomography (PET/CT) have recently been developed to assess radiation-induced damage to salivary structures. The primary aim of this review was to summarize evidence on the imaging modalities used for the assessment and prediction of xerostomia after head and neck radiotherapy (RT).

Methods

A systematic review of the literature was performed using successively the MeSH terms “PET,” “MRI,” “scintigraphy,” “xerostomia,” and “radiotherapy.”

Results

Salivary excretion flow following head and neck RT is correlated with the dose delivered to both parotid and submandibular glands. Salivary gland standardized uptake value extracted from PET/CT following RT has been shown to be correlated with SEF. Models including early SUV decline or ADC increase during RT and clinical parameters can help predict the loss of salivary function after RT.

Conclusions

Modern imaging parameters appear to be correlated with salivary gland scintigraphy parameters. Models including functional parameters extracted from either PET/CT or MRI unveil new possibilities for adaptive treatment in a selected population of patients.

Abstract Image

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背景：最近开发了磁共振成像（MRI）或正电子发射断层扫描/计算机断层扫描（PET/CT）等现代成像技术，用于评估辐射对唾液结构造成的损伤。本综述的主要目的是总结用于评估和预测头颈部放疗（RT）后口干的影像学模式的证据：方法：依次使用MeSH术语 "PET"、"MRI"、"闪烁扫描"、"口腔异味 "和 "放疗 "对文献进行了系统回顾：头颈部放疗后唾液排泄流量与腮腺和颌下腺所受剂量有关。从 RT 后 PET/CT 提取的唾液腺标准化摄取值已被证明与 SEF 相关。包括RT期间早期SUV下降或ADC增加以及临床参数在内的模型有助于预测RT后唾液腺功能的丧失：结论：现代成像参数似乎与唾液腺闪烁扫描参数相关。包括从 PET/CT 或 MRI 提取的功能参数在内的模型为选定患者群体的适应性治疗提供了新的可能性。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.