Self-Cross-Linked Collagen Sponge from the Alosa sapidissima Scale for Hemostasis and Wound Healing Applications.

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2024-12-16 DOI:10.1021/acs.biomac.4c01211

Xiaoyun Li, Yue Xu, Zijun Zhou, Mingliang Tang, Jinjia Cui, Wenjing Han, Jingyi Li, Jing Dai, Xiaoyi Ren, Huihui Jiang, Yanzhen Yu, Qinghua Liu, Hongmei Tang, Miao Xiao

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引用次数: 0

Abstract

Type I collagen, a crucial component maintaining the structural integrity and physiological function of various tissues, is widely regarded as one of the most suitable biomaterials for healthcare applications. In this study, shad scales, used for treating ulcers, scalds, and burns in traditional Chinese medicine, were exploited for type I collagen extraction. After self-assembly into hydrogels, the extracted collagen was subsequently freeze-dried to form collagen sponges. The collagen sponge promoted rapid hemostasis, neovascularization, and immune regulation. Additionally, it accelerated the formation of granulation tissue, re-epithelialization, and collagen remodeling at the wound site in full-thickness skin wound rat models. Consequently, the shad scale collagen sponge holds great promise for the treatment of chronic wounds and skin regeneration. Notably, the shad was sourced from sustainably recirculating aquaculture systems (RAS) farms that adhere to the Traceable Management of Animal Products Safety, ensuring that the derived collagen possesses potential in the medical apparatus market.

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I 型胶原蛋白是维持各种组织结构完整性和生理功能的重要成分，被广泛认为是最适合医疗保健应用的生物材料之一。本研究利用传统中药中用于治疗溃疡、烫伤和烧伤的鲥鱼鳞片提取 I 型胶原蛋白。提取的胶原蛋白在自组装成水凝胶后，经冷冻干燥形成胶原蛋白海绵。胶原蛋白海绵可促进快速止血、新生血管形成和免疫调节。此外，在大鼠全厚皮肤伤口模型中，它还能加速伤口部位肉芽组织的形成、上皮再形成和胶原重塑。因此，鲥鱼鳞胶原蛋白海绵在治疗慢性伤口和皮肤再生方面大有可为。值得注意的是，鲥鱼来自可持续的循环水养殖系统（RAS）养殖场，这些养殖场遵守动物产品安全可追溯管理规定，确保了提取的胶原蛋白在医疗器械市场上的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.