Yuta Sato, Momoko Nagafuchi, Masaharu Takatsuki, Tsuyoshi Matsuzaki, Takeyuki Suzuki, Makoto Sako and Mitsuhiro Arisawa
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引用次数: 0
Abstract
Remote C(sp3)–H bond functionalization reactions are environmentally benign methods for not only acyclic molecules but also cyclic molecules. However, products in previous reports have been limited to aliphatic five-membered ring structures. Herein, we developed an unprecedented multitasking rhodium-catalyzed reaction that can synthesize benzene-fused heterocyclic compounds, 2,3-disubstituted dihydrobenzofurans, through a remote C(sp3)–H bond functionalization reaction (chain-walking/cycloisomerization/hydroboration reaction). This catalytic system promotes a twice-occurring chain-walking/functionalization set in one pot, thus allowing the synthesis of dihydrobenzofurans with various side chain lengths at the 2- and 3-positions.
期刊介绍：
Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.
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