{"title":"Road Guarder (Conophis lineatus concolor: Dipsadidae): Case Documentation of a Clinically Significant Envenoming.","authors":"D E Keyler","doi":"10.1016/j.toxicon.2024.108215","DOIUrl":null,"url":null,"abstract":"<p><p>Detailed cases of envenoming by a non-front-fanged snake (NFFS) from North, Central, and South America have had limited representation in the toxicology and toxinology literature. The NFFS, Conophis lineatus, has been reported to deliver bites that resulted in moderately severe envenoming. However, most of these reported cases have been via personal communication, or self-reported and lacking in detailed medical evaluations. Reported here is a case of an amateur naturalist who was traveling in Mexico and was envenomed following extensive protracted bites to both hands from a wild Conophis lineatus concolor. There was rapid development of extensive localized edema, intense pain, and ecchymoses. The patient was transported to a hospital and after arrival the administration of antivenom was considered due to the severe appearance of local symptoms. The patient requested the medical team contact a consultant toxinologist who advised against the administration of antivenom because of the absence of any supporting evidence demonstrating therapeutic benefit in treating envenoming by C. l. concolor. Consequently, all treatments were limited to supportive symptomatic care. Despite the development of prominent localized symptoms, all laboratory evaluations, including coagulopathy assessment values, revealed no remarkable abnormal alterations. The patient was discharged after two days and symptoms gradually resolved with two months of supportive care.</p>","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":" ","pages":"108215"},"PeriodicalIF":2.6000,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicon","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.toxicon.2024.108215","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Detailed cases of envenoming by a non-front-fanged snake (NFFS) from North, Central, and South America have had limited representation in the toxicology and toxinology literature. The NFFS, Conophis lineatus, has been reported to deliver bites that resulted in moderately severe envenoming. However, most of these reported cases have been via personal communication, or self-reported and lacking in detailed medical evaluations. Reported here is a case of an amateur naturalist who was traveling in Mexico and was envenomed following extensive protracted bites to both hands from a wild Conophis lineatus concolor. There was rapid development of extensive localized edema, intense pain, and ecchymoses. The patient was transported to a hospital and after arrival the administration of antivenom was considered due to the severe appearance of local symptoms. The patient requested the medical team contact a consultant toxinologist who advised against the administration of antivenom because of the absence of any supporting evidence demonstrating therapeutic benefit in treating envenoming by C. l. concolor. Consequently, all treatments were limited to supportive symptomatic care. Despite the development of prominent localized symptoms, all laboratory evaluations, including coagulopathy assessment values, revealed no remarkable abnormal alterations. The patient was discharged after two days and symptoms gradually resolved with two months of supportive care.
期刊介绍:
Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee.
Toxicon''s "aims and scope" are to publish:
-articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms
-papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins
-molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins
-clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained.
-material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems.
-articles on the translational application of toxins, for example as drugs and insecticides
-epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged.
-articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon.
-review articles on problems related to toxinology.
To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.