Actigraphy validation in behavioral variant frontotemporal dementia.

IF 3.8 2区 医学 Q1 CLINICAL NEUROLOGY
Ludovica Tamburrino, Benedetta Tafuri, Valentina Gnoni, Salvatore Nigro, Alessia Giugno, Daniele Urso, Stefano Zoccolella, Marco Filardi, Giancarlo Logroscino
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Abstract

Background: Actigraphy is increasingly being used to assess sleep in patients with neurodegenerative diseases. However, information on its accuracy relative to polysomnography (PSG) in this clinical population remains scarce. This study investigates the performance of actigraphy compared to PSG in patients with behavioral variant frontotemporal dementia (bvFTD), which is the leading form of early-onset dementia.

Methods: Eighteen patients with bvFTD (10 males, mean age 70.50 ± 8.48 years) underwent overnight, in-home PSG while concurrently wearing an actigraph on their non-dominant wrist. Actigraphy performance was assessed through discrepancy analysis, Bland-Altman plots, and epoch-by-epoch analysis (EBE). Analyses were conducted separately for the Cole-Kripke and UCSD scoring algorithms.

Results: Discrepancy analysis highlighted that the Cole-Kripke and UCSD algorithms overestimate total sleep time (by 43 and 60 min, respectively) and sleep efficiency (by 7.13 % and 10.33 %, respectively). The Cole-Kripke algorithm also overestimates sleep onset latency (by 7.75 min). Wake after sleep onset (WASO) showed a negative proportional bias for both algorithms, indicating that actigraphy underestimates WASO for subjects with longer PSG-measured WASO. In the EBE analysis, the Cole-Kripke algorithm shows an accuracy of 84 % (sensitivity 93 %, specificity 62 %) and the UCSD algorithm an accuracy of 85 % (sensitivity 96 %, specificity 57 %).

Conclusions: In patients with bvFTD, actigraphy significantly overestimates total sleep time, sleep latency, and sleep efficiency, while underestimating WASO. Clinicians and researchers using actigraphy to study sleep in bvFTD must carefully consider these measurement biases and correct for them based on the results of previous comparison studies.

行为变异型额颞叶痴呆症的动图验证。
背景:动图越来越多地被用于评估神经退行性疾病患者的睡眠情况。然而,在这一临床人群中,有关其相对于多导睡眠图(PSG)的准确性的信息仍然很少。本研究调查了行为变异性额颞叶痴呆症(bvFTD)患者的动静描记法与多导睡眠图(PSG)的性能比较:18名行为变异性额颞叶痴呆症患者(10名男性,平均年龄(70.50 ± 8.48)岁)在非优势腕部佩戴动觉仪的同时,接受了通宵居家 PSG 检查。通过差异分析、布兰-阿尔特曼图和逐时段分析(EBE)对动图性能进行评估。对 Cole-Kripke 和 UCSD 评分算法分别进行了分析:差异分析显示,Cole-Kripke 和 UCSD 算法高估了总睡眠时间(分别为 43 分钟和 60 分钟)和睡眠效率(分别为 7.13% 和 10.33%)。Cole-Kripke 算法还高估了睡眠开始潜伏期(7.75 分钟)。两种算法的睡眠开始后唤醒(WASO)都出现了负比例偏差,这表明对于 PSG 测定的 WASO 较长的受试者,动图法低估了 WASO。在 EBE 分析中,Cole-Kripke 算法的准确率为 84%(灵敏度 93%,特异性 62%),UCSD 算法的准确率为 85%(灵敏度 96%,特异性 57%):结论:对于 bvFTD 患者,动图法明显高估了总睡眠时间、睡眠潜伏期和睡眠效率,同时低估了 WASO。临床医生和研究人员使用动作描记术研究 bvFTD 患者的睡眠情况时,必须仔细考虑这些测量偏差,并根据之前的对比研究结果加以纠正。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sleep medicine
Sleep medicine 医学-临床神经学
CiteScore
8.40
自引率
6.20%
发文量
1060
审稿时长
49 days
期刊介绍: Sleep Medicine aims to be a journal no one involved in clinical sleep medicine can do without. A journal primarily focussing on the human aspects of sleep, integrating the various disciplines that are involved in sleep medicine: neurology, clinical neurophysiology, internal medicine (particularly pulmonology and cardiology), psychology, psychiatry, sleep technology, pediatrics, neurosurgery, otorhinolaryngology, and dentistry. The journal publishes the following types of articles: Reviews (also intended as a way to bridge the gap between basic sleep research and clinical relevance); Original Research Articles; Full-length articles; Brief communications; Controversies; Case reports; Letters to the Editor; Journal search and commentaries; Book reviews; Meeting announcements; Listing of relevant organisations plus web sites.
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