Ability of brazilian Bothrops-Lachesis-Crotalus antivenom in neutralizing some biological activities of Crotalus durissus ruruima rattlesnake venom.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2024-12-17 DOI:10.1016/j.toxicon.2024.108211

Emiro G Muniz, Ida S Sano-Martins, Maria das Graças G Saraiva, Evela S Magno, Sâmella S Oliveira

引用次数: 0

Abstract

We evaluated the efficacy of freeze-dried Bothrops-Lachesis-Crotalus antivenom and liquid Crotalus antivenoms to neutralize Crotalus durissus ruruima (Cdr) venom (Roraima, Brazil) comparing with C. d. terrificus (Cdt) venom. Lethal and phospholipase A₂ activities were similar between both spp. Crotamine was negative and individual Cdr venoms induced hemorrhage in mice. It was lower coagulant than Cdt venom. Only Bothrops-Lachesis-Crotalus antivenom neutralized all biological activities evaluated, suggesting that it could be used in snakebites in this region.

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巴西 Bothrops-Lachesis-Crotalus 抗蛇毒血清中和 Crotalus durissus ruruima 响尾蛇毒液某些生物活性的能力。

我们评估了冻干的Bothrops-Lachesis-Crotalus抗蛇毒血清和液体Crotalus抗蛇毒血清中和Crotalus durissus ruruima (Cdr)毒液（巴西罗赖马）与C.两种毒液的致死活性和磷脂酶 A2 活性相似，克罗他敏呈阴性，个别 Cdr 毒液会诱发小鼠出血。它的凝血作用比 Cdt 毒液低。只有Bothrops-Lachesis-Crotalus抗蛇毒血清能中和所有评估的生物活性，这表明它可用于该地区的蛇咬伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

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