Evaluation of mild cognitive impairment in older patients with essential tremor.

IF 3.1 3区 医学 Q2 CLINICAL NEUROLOGY
Miki Hashida, Satoshi Maesawa, Satomi Mizuno, Sachiko Kato, Yoshiki Ito, Manabu Mutoh, Takahiro Suzuki, Tomotaka Ishizaki, Takafumi Tanei, Takashi Tsuboi, Masashi Suzuki, Daisuke Nakatsubo, Takahiko Tsugawa, Epifanio Bagarinao, Toshihiko Wakabayashi, Masahisa Katsuno, Ryuta Saito
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Abstract

Introduction: Recent studies have reported that essential tremor (ET) presents with not only motor symptoms but also cognitive dysfunction. However, detailed pathological mechanisms remain unclear. Here, we evaluate the characteristics of cognitive changes in older patients.

Methods: Eighty-five patients aged 65 years or older with ET but without dementia were evaluated for cognitive function using the Addenbrooke Cognitive Examination Revised (ACE-R). The patients were compared with healthy controls (HCs), and the characteristics of cognitive dysfunction were examined. Age at onset and correlations with tremor severity were also investigated. Moreover, we performed resting-state network (RSNs) analysis in a subset of these patients, and the functional connectivity (FC) within the networks was compared with age-matched controls.

Results: Compared to HCs, older patients with ET showed a clear reduction in the total (p = 0.001), attention (p = 0.005), verbal fluency (p = 0.001), and memory (p = 0.001) ACE-R scores. Older-onset patients showed significant cognitive dysfunction compared with younger-onset patients. Verbal fluency correlated with tremor severity in the multiple regression analysis (p < 0.001). RSNs showed an increase in FC in the frontal lobes within the language network in patients with ET compared to HCs (p < 0.05, FWE-corrected).

Conclusion: Older patients with ET showed obvious cognitive dysfunction compared to HCs, indicating that cognitive dysfunction varies by age of onset and correlates with tremor severity. The results of the RSNs analysis suggest that the pathological mechanism of cognitive dysfunction in ET patients involves network changes similar to those in the early stages of Alzheimer's disease.

评估老年本质性震颤患者的轻度认知障碍。
引言最近的研究表明,本质性震颤(ET)不仅表现为运动症状,还伴有认知功能障碍。然而,详细的病理机制仍不清楚。在此,我们评估了老年患者认知变化的特征:方法:我们使用 Addenbrooke 认知检查修订版(ACE-R)对 85 名 65 岁或以上的 ET 患者进行了认知功能评估。将患者与健康对照组(HCs)进行比较,并检查认知功能障碍的特征。我们还研究了发病年龄以及与震颤严重程度的相关性。此外,我们还对其中一部分患者进行了静息态网络(RSNs)分析,并将网络内的功能连通性(FC)与年龄匹配的对照组进行了比较:与对照组相比,老年 ET 患者的 ACE-R 总分(p = 0.001)、注意力(p = 0.005)、语言流畅性(p = 0.001)和记忆力(p = 0.001)明显下降。与年轻患者相比,老年患者表现出明显的认知功能障碍。在多元回归分析中,语言流畅性与震颤严重程度相关(p 结论:震颤严重程度与语言流畅性相关:与 HCs 相比,老年 ET 患者表现出明显的认知功能障碍,这表明认知功能障碍因发病年龄而异,并与震颤严重程度相关。RSNs 分析结果表明,ET 患者认知功能障碍的病理机制涉及与阿尔茨海默病早期阶段类似的网络变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Parkinsonism & related disorders
Parkinsonism & related disorders 医学-临床神经学
CiteScore
6.20
自引率
4.90%
发文量
292
审稿时长
39 days
期刊介绍: Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.
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