Pluronic F-127 coated zinc oxide nanoparticles from Gynura pseudochina: a comprehensive assessment of antibacterial, and anticancer activities.

Abstract

The study synthesized Pluronic F-127 coated zinc oxide nanoparticles (PF-127ZnO NPs) using Gynura pseudochina leaf extract and evaluated their antibacterial, antioxidant, and anticancer properties using various characterization methods such as UV-Vis, Fourier Transform Infra-Red, Photoluminescence spectroscopy, FESEM, EDAX, TEM, SAED, XRD, and DLS. The disc diffusion technique was used to evaluate the antibacterial properties of synthesized Pluronic F-127 coated zinc oxide nanoparticles against various pathogens and significant anticancer activity was noticed. The study examined the cytotoxicity of PF127ZnO nanoparticles to Hep3B cells in vitro. The cytotoxicity was IC50 at 10 µM concentration. The study examined the biocompatibility of PF-127ZnO NPs, revealing membrane blebbing, chromatin condensation, and stimulation of the proapoptotic protein caspase cascade family. The study reveals that PF-127ZnO NPs, synthesized from G. pseudochina leaf extract, exhibit antibacterial and antihepatic properties, offering potential biomedical applications due to their high stability and biocompatibility.