Unveiling cognitive disengagement syndrome: A hidden challenge in children with epilepsy.

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2024-12-13 DOI:10.1016/j.yebeh.2024.110182

Cansu Mercan Isik, Dilek Cebeci

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引用次数: 0

Abstract

Background: In our study, we aimed to investigate the prevalence of cognitive disengagement syndrome (CDS) and attention deficit hyperactivity disorder (ADHD) in children with epilepsy and to identify the associated factors.

Method: The study included 62 patients with epilepsy aged 6-18 and 51 healthy controls. Sociodemographic data, epilepsy characteristics, and medication usage were collected. Psychiatric evaluations used various structured interviews and scales.

Results: The mean ages for patients and controls were 9.7 and 9.9 years, respectively. CDS was present in 76 % of patients with epilepsy compared to 26 % of controls (p < 0.01). Patients with epilepsy scored higher on Barkley Child Attention Scale (BCAS) and Turgay DSM-IV Disruptive Behavior Disorders Symptom Screening Scale (T-DSM-IV-S). CDS prevalence was higher in patients without seizure control and those over age 12. Linear regressions demonstrated that age predicted BCAS-sluggish scores (R²: 0.284, p < 0.001) and T-DSM-IV-S hyperactivity scores (R²: 0.065, p: 0.023). The number of antiseizure medications (R²: 0.065, p: 0.023) and the duration of antiseizure medication usage (R²: 0.079, p: 0.014) predicted T-DSM-IV-S oppositional scores.

Conclusion: Our study is the first study in this field. Our study findings highlight the need for further research to understand the pathophysiological mechanisms underlying CDS in epilepsy and to develop targeted interventions.

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揭开认知分离综合征的面纱：癫痫儿童面临的隐性挑战。

研究背景我们的研究旨在调查认知脱离综合征（CDS）和注意缺陷多动障碍（ADHD）在癫痫患儿中的患病率，并找出相关因素：研究对象包括 62 名 6-18 岁的癫痫患者和 51 名健康对照者。研究收集了社会人口学数据、癫痫特征和药物使用情况。心理评估采用了各种结构化访谈和量表：患者和对照组的平均年龄分别为 9.7 岁和 9.9 岁。76%的癫痫患者存在CDS，而对照组中只有26%（P 2：0.284，P 2：0.065，P：0.023）。抗癫痫药物的数量（R2：0.065，P：0.023）和使用抗癫痫药物的持续时间（R2：0.079，P：0.014）可预测T-DSM-IV-S对抗性评分：我们的研究是该领域的首次研究。结论：我们的研究是该领域的第一项研究，我们的研究结果强调了进一步研究的必要性，以了解癫痫患者CDS的病理生理机制，并制定有针对性的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.