Sourav Kundu, Basanta Kumar Das, Subhadeep Das Gupta
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引用次数: 0
Abstract
Fish oocyte maturation (FOM) is a critical biological process that occurs before ovulation and is influenced by gonadotropins, particularly luteinizing hormone (LH). The release of LH stimulates the ovarian follicle to produce a maturation-inducing hormone (MIH), specifically 17α, 20β-dihydroxy-4-pregnen-3-one (17α, 20β-DP), which initiates the formation of maturation-promoting factor (MPF) through the activation of cyclin B and cdc2 kinase. Insulin-like growth factor I (IGF-I) significantly regulates ovarian functions, including steroidogenesis, by activating its membrane receptors and the tyrosine kinase pathway. IGF-I influences oocyte maturation directly via the PI3 kinase pathway, independent of steroid hormones. Additionally, epidermal growth factor (EGF) promotes cell growth and differentiation by binding to its receptor (EGFR). It is implicated in mediating human chorionic gonadotropin (hCG)-induced DNA synthesis in ovarian follicles while suppressing apoptosis. The presence of EGF in follicle cells and oocytes, along with its higher expression in oocytes, suggests it may act as a paracrine signal regulating somatic cell activity. Recent studies indicate that the activin system in follicle cells could be a target for EGF activity. The EGFR signaling pathway enhances gonadotropin-induced steroidogenesis and governs the transition of oocyte maturation stages, essential for successful fertilization. This review synthesizes current research on the roles of gonadotropins, IGFs, and EGFs in fish oocyte maturation and ovarian steroid production.
期刊介绍：
Animal Reproduction Science publishes results from studies relating to reproduction and fertility in animals. This includes both fundamental research and applied studies, including management practices that increase our understanding of the biology and manipulation of reproduction. Manuscripts should go into depth in the mechanisms involved in the research reported, rather than a give a mere description of findings. The focus is on animals that are useful to humans including food- and fibre-producing; companion/recreational; captive; and endangered species including zoo animals, but excluding laboratory animals unless the results of the study provide new information that impacts the basic understanding of the biology or manipulation of reproduction.
The journal''s scope includes the study of reproductive physiology and endocrinology, reproductive cycles, natural and artificial control of reproduction, preservation and use of gametes and embryos, pregnancy and parturition, infertility and sterility, diagnostic and therapeutic techniques.
The Editorial Board of Animal Reproduction Science has decided not to publish papers in which there is an exclusive examination of the in vitro development of oocytes and embryos; however, there will be consideration of papers that include in vitro studies where the source of the oocytes and/or development of the embryos beyond the blastocyst stage is part of the experimental design.
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