The entorhinal cortex and cognitive impairment in schizophrenia: A comprehensive review

IF 5.3 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry Pub Date : 2025-01-10 DOI:10.1016/j.pnpbp.2024.111218

Kun Li , Liju Qian , Chenchen Zhang , Jiajia Zhang , Chuang Xue , Yuebing Zhang , Wei Deng

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Abstract

Schizophrenia, a severe mental illness characterized by cognitive impairment and olfactory dysfunction, remains an enigma with its pathological mechanism yet to be fully elucidated. The entorhinal cortex, a pivotal structure involved in numerous neural loop circuits related to olfaction, cognition, and emotion, has garnered significant attention due to its structural and functional abnormalities, which have been implicated in the pathogenesis of schizophrenia. This review focuses on the abnormal structural and functional changes in the entorhinal cortex in schizophrenia patients, as evidenced by neuroimaging, cellular biology, and genetic studies. These changes are posited to play a crucial role in the pathogenesis of cognitive impairment in schizophrenia. Furthermore, this review explores the various intervention strategies targeting the entorhinal cortex in current treatment modalities and proposes potential directions for future research endeavors, thereby providing a novel perspective on unraveling the complexity of neural mechanisms underlying schizophrenia and developing innovative therapeutic approaches for schizophrenia.

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精神分裂症患者的内嗅皮质与认知障碍：一项综合综述。

精神分裂症是一种以认知障碍和嗅觉功能障碍为特征的严重精神疾病，其病理机制仍是一个未解之谜。内嗅皮层是一个涉及许多与嗅觉、认知和情感相关的神经回路的关键结构，由于其结构和功能异常而引起了极大的关注，这与精神分裂症的发病机制有关。本文综述了神经影像学、细胞生物学和遗传学研究证明的精神分裂症患者内嗅皮层结构和功能的异常变化。这些变化被认为在精神分裂症认知障碍的发病机制中起着至关重要的作用。此外，本文还探讨了目前针对内嗅皮层的各种干预策略，并提出了未来研究的潜在方向，从而为揭示精神分裂症神经机制的复杂性和开发精神分裂症的创新治疗方法提供了一个新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Neuro-Psychopharmacology & Biological Psychiatry 医学-精神病学

CiteScore

12.00

自引率

1.80%

发文量

153

审稿时长

56 days

期刊介绍： Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.