Correlation of IL-10 and IL18 with the development of liver cirrhosis associated with hepatitis B virus infection: A systematic review.

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2024-12-12 DOI:10.1016/j.cyto.2024.156818

Mohammad Heiat, Mohammad Javanbakht, Davood Jafari, Mohadeseh Poudineh, Fatemeh Heydari, Heidar Sharafi, Seyed Moayed Alavian

{"title":"Correlation of IL-10 and IL18 with the development of liver cirrhosis associated with hepatitis B virus infection: A systematic review.","authors":"Mohammad Heiat, Mohammad Javanbakht, Davood Jafari, Mohadeseh Poudineh, Fatemeh Heydari, Heidar Sharafi, Seyed Moayed Alavian","doi":"10.1016/j.cyto.2024.156818","DOIUrl":null,"url":null,"abstract":"Background: Patients who have been infected with the Hepatitis B virus (HBV) are susceptible to developing liver cirrhosis (LC) and hepatocellular carcinoma (HCC). The objective of this systematic review was to comprehensively scrutinize the existing evidence concerning the association between host genetic polymorphisms and HBV-associated LC.Methods: We searched databases of PubMed, Scopus, and Web of Science for relevant articles published from building databases to 25 October 2023.Result: We detected 104 relevant articles, relating to 84 individuals genes. Nine genes had the strong evidence of correlation, including IL-10, IL-18, IL-1B, TGF- β, TLR3, STAT4, IL-1RN, Tim3, and IFN receptors. A positive correlation was found for 33 genes but this data had not yet been replicated, 11 genes had limited or mixed evidence of a correlation, and 34 genes indicated no correlation. IL-10 and IL-18 had the most evidence of correlation. There was a notable amount of diversity in both the design and method of studies and data quality.Conclusion: IL-10 and IL-18 had the most evidence of correlation. There was a notable amount of diversity in both the design and method of studies and data quality. It is of necessary to take into account the fundamental mechanism behind these associations and discern those that are confounded by the coexistence of other LC/HCC risk factors and response to therapy. These results are expected to guide future studies on the genetic susceptibility of HBV-related LC/HCC.","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"186 ","pages":"156818"},"PeriodicalIF":3.7000,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cytokine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.cyto.2024.156818","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Patients who have been infected with the Hepatitis B virus (HBV) are susceptible to developing liver cirrhosis (LC) and hepatocellular carcinoma (HCC). The objective of this systematic review was to comprehensively scrutinize the existing evidence concerning the association between host genetic polymorphisms and HBV-associated LC.

Methods: We searched databases of PubMed, Scopus, and Web of Science for relevant articles published from building databases to 25 October 2023.

Result: We detected 104 relevant articles, relating to 84 individuals genes. Nine genes had the strong evidence of correlation, including IL-10, IL-18, IL-1B, TGF- β, TLR3, STAT4, IL-1RN, Tim3, and IFN receptors. A positive correlation was found for 33 genes but this data had not yet been replicated, 11 genes had limited or mixed evidence of a correlation, and 34 genes indicated no correlation. IL-10 and IL-18 had the most evidence of correlation. There was a notable amount of diversity in both the design and method of studies and data quality.

Conclusion: IL-10 and IL-18 had the most evidence of correlation. There was a notable amount of diversity in both the design and method of studies and data quality. It is of necessary to take into account the fundamental mechanism behind these associations and discern those that are confounded by the coexistence of other LC/HCC risk factors and response to therapy. These results are expected to guide future studies on the genetic susceptibility of HBV-related LC/HCC.

查看原文本刊更多论文

IL-10和IL18与乙型肝炎病毒感染相关肝硬化发展的相关性：系统综述。

背景：感染乙型肝炎病毒（HBV）的患者容易发展为肝硬化（LC）和肝细胞癌（HCC）。本系统综述旨在全面审查宿主基因多态性与 HBV 相关性 LC 之间关系的现有证据：我们在 PubMed、Scopus 和 Web of Science 数据库中检索了从建立数据库到 2023 年 10 月 25 日发表的相关文章：结果：我们发现了 104 篇相关文章，涉及 84 个基因。9个基因具有较强的相关性，包括IL-10、IL-18、IL-1B、TGF- β、TLR3、STAT4、IL-1RN、Tim3和IFN受体。发现 33 个基因呈正相关，但这一数据尚未得到重复，11 个基因的相关性证据有限或不一，34 个基因无相关性。IL-10 和 IL-18 的相关性证据最多。研究的设计和方法以及数据质量都存在显著差异：IL-10和IL-18的相关性证据最多。结论：IL-10和IL-18的相关性证据最多，研究的设计和方法以及数据质量都存在显著差异。有必要考虑到这些相关性背后的基本机制，并辨别那些因同时存在其他 LC/HCC 危险因素和对治疗的反应而产生的混淆。这些结果有望为今后有关 HBV 相关 LC/HCC 遗传易感性的研究提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.