Polycyclic aromatic hydrocarbons exposure in early pregnancy on child neurodevelopment

IF 7.6 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Zhi Li, Yu Han, Xinyu Li, Wenjuan Xiong, Tingkai Cui, Wei Xi, Shihao Jin, Xin Zhang
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Abstract

The epidemiological evidence from studies on the impact of exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy on child neurodevelopment is inconclusive. This study aimed to assess the associations of PAHs exposure in early pregnancy and neurodevelopmental outcomes in children aged 6-12 months in a prospective cohort. In this study, we included 172 mother-child pairs with complete data in Tianjin City, China. Ten PAH metabolites were determined in early-pregnancy urine using gas chromatography and tandem mass spectrometry (GC–MS/MS). Child neurodevelopment was measured using the Griffiths Development Scales-Chinese (GDS-C) when children were between 6 and 12 months old. We employed multivariable linear regression, Weighted Quantile Sum (WQS) regression, and Bayesian Kernel Machine Regression (BKMR) to assess the relationships of individual PAH metabolites and mixtures of these metabolites with child neurodevelopment. Multiplicative interactions were analyzed to examine effect modification by child sex. In the multivariable linear regression analysis, six PAH metabolites were found to be negatively associated with personal social scores, while three PAH metabolites showed a negative association with language scores. The Weighted Quantile Sum (WQS) model revealed that the PAH mixture was linked to decreased personal social scores (β = - 4.18, 95% CI = -7.56, - 0.80) and language scores (β = - 4.17, 95% CI = -7.98, -0.37). Furthermore, the Bayesian Kernel Machine Regression (BKMR) models also indicated the negative associations between the PAHs mixture and personal social scores and language scores. Notably, three PAH metabolites (1-hydroxynaphthalene(1-OHNap),3-hydroxyfluorene(3-OHFlu), 3+9-hydroxyphenanthrene(3+9-OHPhe)) were identified as important contributors to these associations. All analyses of interactions were null. Exposure to PAHs during early pregnancy, whether individually or as a mixture, demonstrated a negative association with child neurodevelopment outcomes.

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来源期刊
Environmental Pollution
Environmental Pollution 环境科学-环境科学
CiteScore
16.00
自引率
6.70%
发文量
2082
审稿时长
2.9 months
期刊介绍: Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.
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