Genome‐Wide Association Study Reveals a Causal Relationship Between Allergic Rhinitis and Hazelnut Allergy

IF 12.6 1区医学 Q1 ALLERGY

Allergy Pub Date : 2024-12-14 DOI:10.1111/all.16411

Yidan Sun, Judith M. Vonk, Elin T. G. Kersten, Cancan Qi, Aline B. Sprikkelman, Gerard H. Koppelman

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引用次数: 0

Abstract

BackgroundLittle is known about the genetics of food allergy (FA) to various allergens and the heterogeneity of FA in adults.ObjectiveWe aimed to investigate genetic susceptibility to FA in an adult population and to assess the association between secondary FA and allergic rhinitis (AR).MethodsFA and allergen‐specific FA were defined based on in‐depth questionnaires and a previously published FA algorithm in the Lifelines. We performed a series of genome‐wide association studies (GWAS) on FA and nine allergen‐specific (e.g., hazelnut) FA in 21,353 adults in Lifelines. Single nucleotide polymorphisms (SNPs) (p < 1E‐5) were replicated in a second independent set of 15,518 adults participating in the Lifelines followed by meta‐analysis of the results of the two datasets. We subsequently investigated the causal relationship of AR to FA using Mendelian randomization (MR) analysis.ResultsWe observed co‐occurrence of tree nuts and apple FA, with over 80% of this group also reporting AR. After meta‐analysis, we identified one genome‐wide significant locus near HLA‐DPA1 associated with self‐reported hazelnut allergy (hazelnutFA), of which the top SNP is rs5025825 (p = 2.51E‐9, OR = 1.43). Two‐sample MR indicated that AR is a significant causal risk factor for hazelnutFA (p‐IVW = 5.27E‐10, β = 5.90, p‐pleiotropy = 0.46).ConclusionOur questionnaire enabled a large GWAS on self‐reported FA in Dutch adults. We report one novel locus in the human leukocyte antigens (HLA) region associated with hazelnutFA, implying an association with antigen recognition. Our findings genetically link secondary FA to AR in adults.

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来源期刊

Allergy 医学-过敏

CiteScore

26.10

自引率

9.70%

发文量

393

审稿时长

2 months

期刊介绍： Allergy is an international and multidisciplinary journal that aims to advance, impact, and communicate all aspects of the discipline of Allergy/Immunology. It publishes original articles, reviews, position papers, guidelines, editorials, news and commentaries, letters to the editors, and correspondences. The journal accepts articles based on their scientific merit and quality. Allergy seeks to maintain contact between basic and clinical Allergy/Immunology and encourages contributions from contributors and readers from all countries. In addition to its publication, Allergy also provides abstracting and indexing information. Some of the databases that include Allergy abstracts are Abstracts on Hygiene & Communicable Disease, Academic Search Alumni Edition, AgBiotech News & Information, AGRICOLA Database, Biological Abstracts, PubMed Dietary Supplement Subset, and Global Health, among others.