Barriers to the Acceptance of Tuberculosis Preventive Treatment: A Multicenter Cross-sectional Study in China.

Biomedical and environmental sciences : BES Pub Date : 2024-11-20 DOI:10.3967/bes2024.150

Jingjuan Ren, Fei Huang, Haifeng Chen, Huimin Zhang, Jianwei Sun, Ahui Zhao, Zuhui Xu, Liqin Liu, Huizhong Wu, Lanjun Fang, Chengguo Wu, Qingya Wang, Wenqian Zhang, Xinhua Sun, Xiaoping Liu, Jizheng Yuan, Bohan Chen, Ni Wang, Yanlin Zhao

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Abstract

Objective: We aimed to understand the willingness and barriers to the acceptance of tuberculosis (TB) preventive treatment (TPT) among people with latent TB infection (LTBI) in China.

Methods: A multicenter cross-sectional study was conducted from May 18, 2023 to December 31, 2023 across 10 counties in China. According to a national technical guide, we included healthcare workers, students, teachers, and others occupations aged 15-65 years as our research participants.

Results: Overall, 17.0% (183/1,077) of participants accepted TPT. There were statistically significant differences in the acceptance rate of TPT among different sexes, ages, educational levels, and occupations ( P < 0.05). The main barriers to TPT acceptance were misconceptions that it had uncertain effects on prevention (57.8%, 517/894), and concerns about side effects (32.7%, 292/894).

Conclusion: An enhanced and comprehensive understanding of LTBI and TPT among people with LTBI is vital to further expand TPT in China. Moreover, targeted policies need to be developed to address barriers faced by different groups of people.

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接受结核病预防治疗的障碍：中国多中心横断面研究。

目的：了解中国潜伏性结核感染（LTBI）人群接受结核病预防治疗（TPT）的意愿和障碍。方法：于2023年5月18日至2023年12月31日在中国10个县进行多中心横断面研究。根据国家技术指南，我们纳入了15-65岁的医疗工作者、学生、教师和其他职业作为我们的研究参与者。结果：总体而言，17.0%（183/ 1077）的参与者接受了TPT。不同性别、年龄、文化程度、职业的TPT接受率差异有统计学意义（P < 0.05）。接受TPT的主要障碍是对其预防效果不确定的误解（57.8%,517/894）和对副作用的担忧（32.7%,292/894）。结论：提高和全面了解LTBI患者对LTBI和TPT的认识对于进一步扩大TPT在中国的应用至关重要。此外，需要制定有针对性的政策，以解决不同人群面临的障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedical and environmental sciences : BES

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