{"title":"An Infiltrative Choroidal Lesion.","authors":"Yanliang Li, Hesham Gabr, William F Mieler","doi":"10.1097/ICB.0000000000001702","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To present a distinctive case of primary choroidal lymphoma diagnosed by choroidal biopsy with MYD88 testing.</p><p><strong>Methods: </strong>We describe the case of a 55-year-old male with unilateral progressive blurry vision. Fundus examination found a whitish/yellowish infiltrative lesion in the posterior pole with macular edema, which had interval improvement with oral prednisone, followed by worsening on OCT with persistent subretinal hyper-reflective materials.</p><p><strong>Results: </strong>As the initial Pars plana vitrectomy/vitreous biopsy and choroidal fine needle aspiration biopsy (FNAB) were inconclusive, the second FNAB was performed with an additional MYD88 genetic test and revealed a rare in-frame deletion of MYD88 (p.D288_T294del) in the choroidal sample.</p><p><strong>Conclusion: </strong>The diagnosis of PCL was eventually established. After treatment with methotrexate, followed by external beam radiotherapy, the choroidal infiltrate was normalized on B scan.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Retinal Cases and Brief Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/ICB.0000000000001702","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: To present a distinctive case of primary choroidal lymphoma diagnosed by choroidal biopsy with MYD88 testing.
Methods: We describe the case of a 55-year-old male with unilateral progressive blurry vision. Fundus examination found a whitish/yellowish infiltrative lesion in the posterior pole with macular edema, which had interval improvement with oral prednisone, followed by worsening on OCT with persistent subretinal hyper-reflective materials.
Results: As the initial Pars plana vitrectomy/vitreous biopsy and choroidal fine needle aspiration biopsy (FNAB) were inconclusive, the second FNAB was performed with an additional MYD88 genetic test and revealed a rare in-frame deletion of MYD88 (p.D288_T294del) in the choroidal sample.
Conclusion: The diagnosis of PCL was eventually established. After treatment with methotrexate, followed by external beam radiotherapy, the choroidal infiltrate was normalized on B scan.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
