{"title":"Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches.","authors":"Yuanyuan Deng, Feifei Wang, Li He","doi":"10.12659/MSM.945336","DOIUrl":null,"url":null,"abstract":"<p><p>Acne vulgaris is a chronic inflammatory disease of the hair follicle-sebaceous gland unit and is the most common skin disorder worldwide. Although it can occur at any age, it predominantly affects young individuals, manifesting as comedones, papules, pustules, cysts, and nodules, primarily in the sebaceous-rich areas of the face, often in a symmetrical distribution. The development of acne vulgaris is believed to result from a combination of genetic and environmental factors, including sun exposure, skincare habits, diet, sleep patterns, and psychological stress, all of which can induce or exacerbate the condition. The pathogenesis of acne vulgaris involves androgen-induced sebaceous gland hyperplasia, excessive sebum production, abnormal follicular duct keratinization, microbial colonization, and immune-inflammatory responses. Historically, treatment has focused on regulating sebum production, improving follicular keratinization, and providing antibacterial and anti-inflammatory therapies, with less attention given to repairing the skin barrier. Treatment outcomes have often been suboptimal, with frequent recurrences, high incidence of skin sensitivity, and significant economic and psychological burdens on patients. This review explores the mechanisms of skin barrier impairment in acne vulgaris and discusses strategies for its repair, offering new perspectives for the clinical management of acne.</p>","PeriodicalId":48888,"journal":{"name":"Medical Science Monitor","volume":"30 ","pages":"e945336"},"PeriodicalIF":3.1000,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Science Monitor","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12659/MSM.945336","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Acne vulgaris is a chronic inflammatory disease of the hair follicle-sebaceous gland unit and is the most common skin disorder worldwide. Although it can occur at any age, it predominantly affects young individuals, manifesting as comedones, papules, pustules, cysts, and nodules, primarily in the sebaceous-rich areas of the face, often in a symmetrical distribution. The development of acne vulgaris is believed to result from a combination of genetic and environmental factors, including sun exposure, skincare habits, diet, sleep patterns, and psychological stress, all of which can induce or exacerbate the condition. The pathogenesis of acne vulgaris involves androgen-induced sebaceous gland hyperplasia, excessive sebum production, abnormal follicular duct keratinization, microbial colonization, and immune-inflammatory responses. Historically, treatment has focused on regulating sebum production, improving follicular keratinization, and providing antibacterial and anti-inflammatory therapies, with less attention given to repairing the skin barrier. Treatment outcomes have often been suboptimal, with frequent recurrences, high incidence of skin sensitivity, and significant economic and psychological burdens on patients. This review explores the mechanisms of skin barrier impairment in acne vulgaris and discusses strategies for its repair, offering new perspectives for the clinical management of acne.
期刊介绍:
Medical Science Monitor (MSM) established in 1995 is an international, peer-reviewed scientific journal which publishes original articles in Clinical Medicine and related disciplines such as Epidemiology and Population Studies, Product Investigations, Development of Laboratory Techniques :: Diagnostics and Medical Technology which enable presentation of research or review works in overlapping areas of medicine and technology such us (but not limited to): medical diagnostics, medical imaging systems, computer simulation of health and disease processes, new medical devices, etc. Reviews and Special Reports - papers may be accepted on the basis that they provide a systematic, critical and up-to-date overview of literature pertaining to research or clinical topics. Meta-analyses are considered as reviews. A special attention will be paid to a teaching value of a review paper.
Medical Science Monitor is internationally indexed in Thomson-Reuters Web of Science, Journals Citation Report (JCR), Science Citation Index Expanded (SCI), Index Medicus MEDLINE, PubMed, PMC, EMBASE/Excerpta Medica, Chemical Abstracts CAS and Index Copernicus.